A ruthenium-catalyzed free amine directed (5+1) annulation of anilines with olefins: diverse synthesis of phenanthridine derivatives

被引：34
作者：
Chowdhury, Deepan [1 ]
Dana, Suman [1 ]
Mandal, Anup [1 ]
Baidya, Mahiuddin [1 ]
机构：
[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 79期
关键词：
H BOND ACTIVATION; ONE-POT SYNTHESIS; OXIDATIVE ANNULATION; ALKYNES; ALKENYLATION; CYCLIZATION; CLEAVAGE; ALKALOIDS; ANTITUMOR; ALKENES;
D O I：
10.1039/c9cc05717j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A ruthenium(ii)-catalyzed cross-ring (5+1) annulation between 2-aminobiphenyls and activated olefins is disclosed for succinct synthesis of valuable phenanthridine scaffolds. The protocol avails a common organic functional group, free amine, as a directing group and represents a unique combination of C-H activation/annulation/C-C bond cleavage cascade that bodes well in the production of bioactive alkaloids including trisphaeridine and bicolorine.
引用
收藏
页码：11908 / 11911
页数：4
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