Teratogenic effects of the Zika virus and the role of the placenta

被引：116

作者：

Adibi, Jennifer J. ^{[1
,2
]}

Marques, Ernesto T. A., Jr. ^{[3
,4
]}

Cartus, Abigail ^{[5
]}

Beigi, Richard H. ^{[2
]}

机构：

[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Obstet & Gynecol & Reprod Sci, Pittsburgh, PA USA

[3] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA USA

[4] Oswaldo Cruz Fdn Fiocruz, Res Ctr Aggeu Magalhaes CPqAM, Recife, PE, Brazil

[5] Univ Texas Hlth Sci Ctr Houston, Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston, TX 77030 USA

来源：

LANCET | 2016年 / 387卷 / 10027期

关键词：

CEREBRAL-CORTEX; INFECTION; PATHOGENESIS; ABNORMALITIES; EXOSOMES; FETUS; STEM;

D O I：

10.1016/S0140-6736(16)00650-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanism by which the Zika virus can cause fetal microcephaly is not known. Reports indicate that Zika is able to evade the normal immunoprotective responses of the placenta. Microcephaly has genetic causes, some associated with maternal exposures including radiation, tobacco smoke, alcohol, and viruses. Two hypotheses regarding the role of the placenta are possible: one is that the placenta directly conveys the Zika virus to the early embryo or fetus. Alternatively, the placenta itself might be mounting a response to the exposure; this response might be contributing to or causing the brain defect. This distinction is crucial to the diagnosis of fetuses at risk and the design of therapeutic strategies to prevent Zika-induced teratogenesis.

引用

页码：1587 / 1590

页数：4

共 29 条

[11] Histological findings in foetuses congenitally infected by cytomegalovirus [J].

Gabrielli, Liliana ;

Bonasoni, Maria Paola ;

Lazzarotto, Tiziana ;

Lega, Stefania ;

Santini, Donatella ;

Foschini, Maria Pia ;

Guerra, Brunella ;

Baccolini, Federica ;

Piccirilli, Giulia ;

Chiereghin, Angela ;

Petrisli, Evangelia ;

Gardini, Giorgio ;

Lanari, Marcello ;

Landini, Maria Paola .

JOURNAL OF CLINICAL VIROLOGY, 2009, 46 :S16-S21

[12] Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 [J].

Garcez, Patricia P. ;

Diaz-Alonso, Javier ;

Crespo-Enriquez, Ivan ;

Castro, Diogo ;

Bell, Donald ;

Guillemot, Francois .

NATURE COMMUNICATIONS, 2015, 6

[13] Genetic causes of microcephaly and lessons for neuronal development [J].

Gilmore, Edward C. ;

Walsh, Christopher A. .

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY, 2013, 2 (04) :461-478

[14]

HADEED AJ, 1989, PEDIATRICS, V84, P205

[15] Dengue Antibody- Dependent Enhancement: Knowns and Unknowns [J].

Halstead, Scott B. .

MICROBIOLOGY SPECTRUM, 2014, 2 (06)

[16] Biology of Zika Virus Infection in Human Skin Cells [J].

Hamel, Rodolphe ;

Dejarnac, Ophelie ;

Wichit, Sineewanlaya ;

Ekchariyawat, Peeraya ;

Neyret, Aymeric ;

Luplertlop, Natthanej ;

Perera-Lecoin, Manuel ;

Surasombatpattana, Pornapat ;

Talignani, Loic ;

Thomas, Frederic ;

Cao-Lormeau, Van-Mai ;

Choumet, Valerie ;

Briant, Laurence ;

Despres, Philippe ;

Amara, Ali ;

Yssel, Hans ;

Misse, Dorothee .

JOURNAL OF VIROLOGY, 2015, 89 (17) :8880-8896

[17] Proliferation control in neural stem and progenitor cells [J].

Homem, Catarina C. F. ;

Repic, Marko ;

Knoblich, Juergen A. .

NATURE REVIEWS NEUROSCIENCE, 2015, 16 (11) :647-659

[18] THE PATHOGENESIS OF BRAIN ABNORMALITIES IN THE FETAL ALCOHOL SYNDROME - AN INTEGRATING HYPOTHESIS [J].

KENNEDY, LA .

TERATOLOGY, 1984, 29 (03) :363-368

[19] Antenatal antecedents of a small head circumference at age 24-months post-term equivalent in a sample of infants born before the 28th post-menstrual week [J].

Leviton, Alan ;

Kuban, Karl ;

Allred, Elizabeth N. ;

Hecht, Jonathan L. ;

Onderdonk, Andrew ;

O'Shea, T. Michael ;

McElrath, Thomas ;

Paneth, Nigel .

EARLY HUMAN DEVELOPMENT, 2010, 86 (08) :515-521

[20] Zika Virus Associated with Microcephaly [J].

Mlakar, Jernej ;

Korva, Misa ;

Tul, Natasa ;

Popovic, Mara ;

Poljsak-Prijatelj, Mateja ;

Mraz, Jerica ;

Kolenc, Marko ;

Rus, Katarina Resman ;

Vipotnik, Tina Vesnaver ;

Vodusek, Vesna Fabjan ;

Vizjak, Alenka ;

Pizem, Joze ;

Petrovec, Miroslav ;

Zupanc, Tatjana Avsic .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (10) :951-958

← 1 2 3 →