Teratogenic effects of the Zika virus and the role of the placenta

被引：116

作者：

Adibi, Jennifer J. ^{[1
,2
]}

Marques, Ernesto T. A., Jr. ^{[3
,4
]}

Cartus, Abigail ^{[5
]}

Beigi, Richard H. ^{[2
]}

机构：

[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Obstet & Gynecol & Reprod Sci, Pittsburgh, PA USA

[3] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA USA

[4] Oswaldo Cruz Fdn Fiocruz, Res Ctr Aggeu Magalhaes CPqAM, Recife, PE, Brazil

[5] Univ Texas Hlth Sci Ctr Houston, Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston, TX 77030 USA

来源：

LANCET | 2016年 / 387卷 / 10027期

关键词：

CEREBRAL-CORTEX; INFECTION; PATHOGENESIS; ABNORMALITIES; EXOSOMES; FETUS; STEM;

D O I：

10.1016/S0140-6736(16)00650-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanism by which the Zika virus can cause fetal microcephaly is not known. Reports indicate that Zika is able to evade the normal immunoprotective responses of the placenta. Microcephaly has genetic causes, some associated with maternal exposures including radiation, tobacco smoke, alcohol, and viruses. Two hypotheses regarding the role of the placenta are possible: one is that the placenta directly conveys the Zika virus to the early embryo or fetus. Alternatively, the placenta itself might be mounting a response to the exposure; this response might be contributing to or causing the brain defect. This distinction is crucial to the diagnosis of fetuses at risk and the design of therapeutic strategies to prevent Zika-induced teratogenesis.

引用

页码：1587 / 1590

页数：4

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