Nutritional immunity beyond iron: a role for manganese and zinc

被引：475

作者：

Kehl-Fie, Thomas E. ^{[1
]}

Skaar, Eric P. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37203 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 02期

关键词：

STREPTOCOCCUS-PYOGENES; SALMONELLA-ENTERICA; CRYSTAL-STRUCTURE; PSORIASIN S100A7; BRUCELLA-ABORTUS; BACTERIAL-GROWTH; YERSINIA-PESTIS; BINDING-PROTEIN; CYSTIC-FIBROSIS; METAL;

D O I：

10.1016/j.cbpa.2009.11.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vertebrates sequester iron from invading pathogens, and conversely, pathogens express a variety of factors to steal iron from the host. Recent work has demonstrated that in addition to iron, vertebrates sequester zinc and manganese both intracellularly and extracellularly to protect against infection. Intracellularly, vertebrates utilize the ZIP/ZnT families of transporters to manipulate zinc levels, as well as Nramp1 to manipulate manganese levels Extracellularly, the S100 protein calprotectin sequesters manganese and potentially zinc to inhibit microbial growth To circumvent these defenses, bacteria possess high affinity transporters to import specific nutrient metals. Limiting the availability of zinc and manganese as a mechanism to defend against infection expands the spectrum of nutritional immunity and further establishes metal sequestration as a key defense against microbial invaders

引用

页码：218 / 224

页数：7

共 61 条

[1] High-affinity Zn2+ uptake system ZnuABC is required for bacterial zinc Homeostasis in intracellular environments and contributes to the virulence of Salmonella enterica [J].

Ammendola, Serena ;

Pasquali, Paolo ;

Pistoia, Claudia ;

Petrucci, Paola ;

Petrarca, Patrizia ;

Rotilio, Giuseppe ;

Battistoni, Andrea .

INFECTION AND IMMUNITY, 2007, 75 (12) :5867-5876

[2] The Manganese Transporter MntH Is a Critical Virulence Determinant for Brucella abortus 2308 in Experimentally Infected Mice [J].

Anderson, Eric S. ;

Paulley, James T. ;

Gaines, Jennifer M. ;

Valderas, Michelle W. ;

Martin, Daniel W. ;

Menscher, Evan ;

Brown, Timothy D. ;

Burns, Colin S. ;

Roop, R. Martin, II .

INFECTION AND IMMUNITY, 2009, 77 (08) :3466-3474

[3] Counting the zinc-proteins encoded in the human genome [J].

Andreini, C ;

Banci, L ;

Bertini, I ;

Rosato, A .

JOURNAL OF PROTEOME RESEARCH, 2006, 5 (01) :196-201

[4] Zinc through the three domains of life [J].

Andreini, Claudia ;

Banci, Lucia ;

Bertini, Ivano ;

Rosato, Antonio .

JOURNAL OF PROTEOME RESEARCH, 2006, 5 (11) :3173-3178

[5] Metal ions in biological catalysis: from enzyme databases to general principles [J].

Andreini, Claudia ;

Bertini, Ivano ;

Cavallaro, Gabriele ;

Holliday, Gemma L. ;

Thornton, Janet M. .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2008, 13 (08) :1205-1218

[6]

Aschner Judy L., 2005, Molecular Aspects of Medicine, V26, P353, DOI 10.1016/j.mam.2005.07.003

[7] Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells [J].

Aydemir, Tolunay B. ;

Liuzzi, Juan P. ;

McClellan, Steve ;

Cousins, Robert J. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (02) :337-348

[8] Copper methanobactin: a molecule whose time has come [J].

Balasubramanian, Ramakrishnan ;

Rosenzweig, Amy C. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2008, 12 (02) :245-249

[9] The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague [J].

Bearden, SW ;

Perry, RD .

MOLECULAR MICROBIOLOGY, 1999, 32 (02) :403-414

[10] Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein:: Identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures [J].

Begum, NA ;

Kobayashi, M ;

Moriwaki, Y ;

Matsumoto, M ;

Toyoshima, K ;

Seya, T .

GENOMICS, 2002, 80 (06) :630-645

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