Nutritional immunity beyond iron: a role for manganese and zinc

被引:473
作者
Kehl-Fie, Thomas E. [1 ]
Skaar, Eric P. [1 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37203 USA
关键词
STREPTOCOCCUS-PYOGENES; SALMONELLA-ENTERICA; CRYSTAL-STRUCTURE; PSORIASIN S100A7; BRUCELLA-ABORTUS; BACTERIAL-GROWTH; YERSINIA-PESTIS; BINDING-PROTEIN; CYSTIC-FIBROSIS; METAL;
D O I
10.1016/j.cbpa.2009.11.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vertebrates sequester iron from invading pathogens, and conversely, pathogens express a variety of factors to steal iron from the host. Recent work has demonstrated that in addition to iron, vertebrates sequester zinc and manganese both intracellularly and extracellularly to protect against infection. Intracellularly, vertebrates utilize the ZIP/ZnT families of transporters to manipulate zinc levels, as well as Nramp1 to manipulate manganese levels Extracellularly, the S100 protein calprotectin sequesters manganese and potentially zinc to inhibit microbial growth To circumvent these defenses, bacteria possess high affinity transporters to import specific nutrient metals. Limiting the availability of zinc and manganese as a mechanism to defend against infection expands the spectrum of nutritional immunity and further establishes metal sequestration as a key defense against microbial invaders
引用
收藏
页码:218 / 224
页数:7
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