Incidence and prevalence of the metabolic syndrome in a cohort of naive HIV-infected patients:: prospective analysis at 48 weeks of highly active antiretroviral therapy

被引：37

作者：

Palacios, R. ^{[1
]}

Santos, J. ^{[1
]}

Gonzalez, M. ^{[1
]}

Ruiz, J. ^{[1
]}

Marquez, M. ^{[1
]}

机构：

[1] Hosp Virgen de la Victoria, Infect Dis Unit, Dept Internal Med, Malaga 29010, Spain

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2007年 / 18卷 / 03期

关键词：

metabolic syndrome; cardiovascular risk; HIV; HAART; hs-CRP;

D O I：

10.1258/095646207780132415

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We undertook a prospective study to assess the prevalence of the metabolic syndrome (MetS) in HIV patients at the start of highly active antiretroviral therapy (HAART), and at 48 weeks, and we also studied its relationship with high-sensitivity C-reactive protein (hs-CRP) in 60 HIV patients who maintained the same regimen during follow-up. The prevalence of MetS rose from 16.6% at baseline to 25% at 48 weeks (P = 0.0001). During follow up, 7/50 patients developed MetS, leading an incidence of 14/100 patients/year. The MetS was associated with age, homosexuality, and lower hepatitis C virus prevalence; only age remained significant in the multivariate analysis (for each five-year increase: beta coefficient 4.26, 95% confidence interval, 3.80-4.75; P = 0.0039). The hs CRP values were similar in patients with and without the MetS, and they did not increase at 48 weeks of HAART.

引用

页码：184 / 187

页数：4

共 24 条

[1]

[Anonymous], 1997, ARCH INTERN MED, V157, P2413, DOI [10.1001/archinte.1997.00440420033005, DOI 10.1001/ARCHINTE.1997.00440420033005]

[2]

Ascaso Juan F, 2003, Eur J Intern Med, V14, P101, DOI 10.1016/S0953-6205(03)00022-0

[3]

Cordella CB, 2004, ARCHAEOLOGY, V57, P8

[4] High prevalence of metabolic syndrome among HIV-infected patients: Link with the cardiovascular risk [J].

Bruno, R ;

Gazzaruso, C ;

Sacchi, P ;

Zocchetti, C ;

Giodanetti, S ;

Garzaniti, V ;

Maffezzini, E ;

Maserati, R ;

Filice, G .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2002, 31 (03) :363-365

[5] Adverse effects of antiretroviral therapy [J].

Carr, A ;

Cooper, DA .

LANCET, 2000, 356 (9239) :1423-1430

[6] Civic networks, legitimacy and the policy process [J].

Carroll, BW ;

Carroll, T .

GOVERNANCE-AN INTERNATIONAL JOURNAL OF POLICY AND ADMINISTRATION, 1999, 12 (01) :1-28

[7] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].

Cleeman, JI ;

Grundy, SM ;

Becker, D ;

Clark, LT ;

Cooper, RS ;

Denke, MA ;

Howard, WJ ;

Hunninghake, DB ;

Illingworth, DR ;

Luepker, RV ;

McBride, P ;

McKenney, JM ;

Pasternak, RC ;

Stone, NJ ;

Van Horn, L ;

Brewer, HB ;

Ernst, ND ;

Gordon, D ;

Levy, D ;

Rifkind, B ;

Rossouw, JE ;

Savage, P ;

Haffner, SM ;

Orloff, DG ;

Proschan, MA ;

Schwartz, JS ;

Sempos, CT ;

Shero, ST ;

Murray, EZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497

[8] Prevalence of the metabolic syndrome among US adults - Findings from the Third National Health and Nutrition Examination Survey [J].

Ford, ES ;

Giles, WH ;

Dietz, WH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (03) :356-359

[9] A comparison of the prevalence of the metabolic syndrome using two proposed definitions [J].

Ford, ES ;

Giles, WH .

DIABETES CARE, 2003, 26 (03) :575-581

[10] Prevalence of metabolic syndrome among HIV patients [J].

Gazzaruso, C ;

Sacchi, P ;

Garzaniti, A ;

Fratino, P ;

Bruno, R ;

Filice, G .

DIABETES CARE, 2002, 25 (07) :1253-1254

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