HAND2-AS1: A functional cancer-related long non-coding RNA

被引：31

作者：

Gu, Xinyu ^{[1
]}

Zheng, Qiuxian ^{[1
]}

Chu, Qingfei ^{[1
]}

Zhu, Haihong ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med,Affiliated Hosp 1,Natl Clin Res Ctr Infe, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 137卷

关键词：

lncRNA HAND2-AS1; Cancers; Function; Molecular mechanisms; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; GENE-EXPRESSION; MIGRATION; REVEALS; TRANSCRIPTION; METASTASIS; GROWTH;

D O I：

10.1016/j.biopha.2021.111317

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Long non-coding RNAs (lncRNAs) regulate gene expression and carcinogenesis. The lncRNA heart and neural crest derivatives expressed transcript 2 antisense RNA 1 (HAND2-AS1) suppresses tumor growth, and its expression level was lower in tumor tissues than in adjacent normal tissues of most types of human cancers, including non-small cell lung cancer, ovarian cancer, breast cancer, gastric cancer, colorectal cancer, cervical cancer, endometrial cancer, prostate cancer, and esophagus squamous cell carcinoma. However, one study reported that the HAND2-AS1 expression was upregulated in hepatocellular carcinoma tissues comparing with non-tumor tissues and it promoted tumor development. The aberrant expression of HAND2-AS1 was strongly linked to tumor progression and prognosis. Moreover, HAND2-AS1 was involved in tumor cell proliferation, differentiation, apoptosis, and cellular glucose metabolism. This review summarizes data on the expression profile, functions, underlying mechanism, and clinical value of HAND2-AS1 in cancer. The expression profile of HAND2-AS1 in 33 tumors was evaluated by bioinformatics analysis of The Cancer Genome Atlas.

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