DNA core ionization and cell inactivation

被引：17
作者：
Boissiere, Arnaud
Champion, Christophe
Touati, Alain
du Penhoat, Marie-Anne Herve
Sabatier, Laure
Chatterjee, Aloke
Chetioui, Annie
机构：
[1] Univ Paris 06, Inst Mineral & Phys Mil Condenses, CNRS, UMR 7590, F-75015 Paris, France
[2] Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA
[3] CEA, DSV, DRR, Lab Radiobiol & Oncol, F-92265 Fontenay Aux Roses, France
[4] Univ Paul Verlaine, Lab Phys Mol & Collis, F-57070 Metz, France
来源：
RADIATION RESEARCH | 2007年 / 167卷 / 04期
关键词：
D O I：
10.1667/RR0451.1
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and gamma rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Carlo track simulations. The probability that a core ionization leads to cell inactivation is deduced from experimental values of the RBEs of ultrasoft X rays. The contribution to V79 cell inactivation solely due to the core ionizations in DNA is found to be 75 +/- 27% for energetic electrons and gamma rays. This surprisingly large contribution strongly suggests the presence of new mechanisms associated with critical lesions for cell inactivation. (c) 2007 by Radiation Research Society.
引用
收藏
页码：493 / 500
页数：8
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