Unactivated Alkyl Halides in Transition-Metal-Catalyzed C-H Bond Alkylation

被引：72

作者：

Ankade, Shidheshwar B. ^{[1
,2
]}

Shabade, Anand B. ^{[1
,2
]}

Soni, Vineeta ^{[1
,2
]}

Punji, Benudhar ^{[1
,2
]}

机构：

[1] CSIR Natl Chem Lab CSIR NCL, Organometall Synth & Catalysis Lab, Chem Engn Div, Pune 411008, Maharashtra, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

ACS CATALYSIS | 2021年 / 11卷 / 06期

关键词：

alkylation; unactivated alkyl halides; C-H activation; (hetero)arenes; transition metals;

D O I：

10.1021/acscatal.0c05580

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Alkylation represents an important organic transformation in molecular science to develop privileged alkylated arenes and heteroarenes. Especially, the direct C-H bond alkylation using unactivated alkyl halides is a straightforward and attractive approach from both the step-economy and chemoselectivity perspectives. Substantial progress has been made in the direct alkylation using primary, secondary, and tertiary alkyl halides along with the methylation and fluoroalkylation. This Review broadly summarizes the transition-metal-catalyzed alkylations of C-H bonds on various arenes and heteroarenes with unactivated alkyl halides until October 2020. On the basis of the substrates utilized for alkylation, the Review is divided into two major sections: alkylation of arenes and alkylation of heteroarenes.

引用

页码：3268 / 3292

页数：25

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