NF-κB in cancer:: From innocent bystander to major culprit

被引：2157
作者：
Karin, M [1 ]
Cao, YX [1 ]
Greten, FR [1 ]
Li, ZW [1 ]
机构：
[1] Univ Calif San Diego, Sch Med, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 04期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc780
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-kappaB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.
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收藏
页码：301 / 310
页数：10
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