Regulation of protein kinases: Controlling activity through activation segment conformation

被引：869

作者：

Nolen, B ^{[1
]}

Taylor, S ^{[1
]}

Ghosh, G ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92116 USA

来源：

MOLECULAR CELL | 2004年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.molcel.2004.08.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the confromation of the activation segment controls kinase activity.

引用

页码：661 / 675

页数：15

共 103 条

[1] Kinetic and catalytic mechanisms of protein kinases [J].

Adams, JA .

CHEMICAL REVIEWS, 2001, 101 (08) :2271-2290

[2] Activation loop phosphorylation and catalysis in protein kinases: Is there functional evidence for the autoinhibitor model? [J].

Adams, JA .

BIOCHEMISTRY, 2003, 42 (03) :601-607

[3] APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase [J].

Ahmed, Z ;

Smith, BJ ;

Kotani, K ;

Wilden, P ;

Pillay, TS .

BIOCHEMICAL JOURNAL, 1999, 341 :665-668

[4] The structure of phosphorylated GSK-3β complexed with a peptide, FRATtide, that inhibits β-catenin phosphorylation [J].

Bax, B ;

Carter, PS ;

Lewis, C ;

Guy, AR ;

Bridges, A ;

Tanner, R ;

Pettman, G ;

Mannix, C ;

Culbert, AA ;

Brown, MJB ;

Smith, DG ;

Reith, AD .

STRUCTURE, 2001, 9 (12) :1143-1152

[5] Structural basis of Aurora-A activation by TPX2 at the mitotic spindle [J].

Bayliss, R ;

Sardon, T ;

Vernos, I ;

Conti, E .

MOLECULAR CELL, 2003, 12 (04) :851-862

[6] The structure of phosphorylated P38γ is monomeric and reveals a conserved activation-loop conformation [J].

Bellon, S ;

Fitzgibbon, MJ ;

Fox, T ;

Hsiao, HM ;

Wilson, KP .

STRUCTURE, 1999, 7 (09) :1057-1065

[7] High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site [J].

Biondi, RM ;

Komander, D ;

Thomas, CC ;

Lizcano, JM ;

Deak, M ;

Alessi, DR ;

van Aalten, DMF .

EMBO JOURNAL, 2002, 21 (16) :4219-4228

[8] The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases [J].

Brown, NR ;

Noble, MEM ;

Endicott, JA ;

Johnson, LN .

NATURE CELL BIOLOGY, 1999, 1 (07) :438-443

[9] Activation mechanism of the MAP kinase ERK2 by dual phosphorylation [J].

Canagarajah, BJ ;

Khokhlatchev, A ;

Cobb, MH ;

Goldsmith, EJ .

CELL, 1997, 90 (05) :859-869

[10] Crystal structure of aurora-2, an oncogenic serine/threonine kinase [J].

Cheetham, GMT ;

Knegtel, RMA ;

Coll, JT ;

Renwick, SB ;

Swenson, L ;

Weber, P ;

Lippke, JA ;

Austen, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (45) :42419-42422

← 1 2 3 4 5 6 7 8 9 10 →