Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures

被引:231
作者
Chhabra, Rahul
Sharma, Jaswinder
Ke, Yonggang
Liu, Yan
Rinker, Sherri
Lindsay, Stuart
Yan, Hao [1 ]
机构
[1] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA
[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA
关键词
D O I
10.1021/ja072410u
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.
引用
收藏
页码:10304 / +
页数:3
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