Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study

被引：444

作者：

Cardis, E. ^{[1
,2
]}

Deltour, I. ^{[2
,3
]}

Vrijheid, M. ^{[1
,2
]}

Combalot, E. ^{[4
]}

Moissonnier, M.

Tardy, H. ^{[5
]}

Armstrong, B. ^{[6
]}

Giles, G. ^{[7
]}

Brown, J. ^{[6
]}

Siemiatycki, J. ^{[8
]}

Parent, M. E. ^{[9
]}

Nadon, L. ^{[9
]}

Krewski, D. ^{[10
]}

McBride, M. L. ^{[11
]}

Johansen, C. ^{[3
]}

Collatz, Christensen H. ^{[3
]}

Auvinen, A. ^{[12
,13
]}

Kurttio, P. ^{[13
]}

Lahkola, A. ^{[13
]}

Salminen, T. ^{[13
]}

Hours, M. ^{[5
]}

Bernard, M. ^{[5
]}

Montestruq, L. ^{[5
]}

Schuez, J. ^{[3
,14
]}

Berg-Beckhoff, G. ^{[15
]}

Schlehofer, B. ^{[16
]}

Blettner, M. ^{[14
]}

Sadetzki, S. ^{[17
,18
]}

Chetrit, A. ^{[17
]}

Jarus-Hakak, A. ^{[17
]}

Lagorio, S. ^{[19
]}

Iavarone, I. ^{[20
]}

Takebayashi, T. ^{[21
]}

Yamaguchi, N. ^{[22
]}

Woodward, A. ^{[23
]}

Cook, A. ^{[24
]}

Pearce, N. ^{[25
]}

Tynes, T. ^{[26
,27
]}

Blaasaas, K. G. ^{[28
]}

Klaeboe, L. ^{[27
]}

Feychting, M. ^{[29
]}

Loenn, S. ^{[30
]}

Ahlbom, A. ^{[29
]}

McKinney, P. A. ^{[31
]}

Hepworth, S. J. ^{[31
]}

Muir, K. R. ^{[32
]}

Swerdlow, A. J. ^{[33
]}

Schoemaker, M. J. ^{[33
]}

机构：

[1] CIBERESP, CREAL, Municipal Inst Med Res IMIM, Barcelona 08003, Spain

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[4] CHU Lyon Sud, GELARC, Pierre Benite, France

[5] Univ Lyon, Inst Natl Rech Transports & Leur Secur, Inst Natl Veille Sanit, Unite Mixte Rech Epidemiol & Surveillance Transpo, Lyon, France

[6] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia

[7] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[8] Univ Montreal, Sch Publ Hlth, Montreal, PQ, Canada

[9] Univ Quebec, Inst Armand Frappier, INRS, Laval, PQ, Canada

[10] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada

[11] BC Canc Agcy, BC Canc Res Ctr, Vancouver, BC, Canada

[12] Univ Tampere, Tampere Sch Publ Hlth, FIN-33101 Tampere, Finland

[13] STUK Radiat & Nucl Safety Author, Helsinki, Finland

[14] Johannes Gutenberg Univ Mainz, Inst Med Biostat Epidemiol & Informat, Mainz, Germany

[15] Univ Bielefeld, Dept Epidemiol & Int Publ Hlth, Fac Publ Hlth, Bielefeld, Germany

[16] German Canc Res Ctr, Environm Epidemiol Unit, D-6900 Heidelberg, Germany

[17] Chaim Sheba Med Ctr, Canc & Radiat Epidemiol Unit, Gertner Inst, IL-52621 Tel Hashomer, Israel

[18] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[19] Natl Inst Hlth, Natl Ctr Epidemiol Surveillance & Hlth Promot, Rome, Italy

[20] Natl Inst Hlth, Dept Environm & Primary Prevent, Rome, Italy

[21] Keio Univ, Sch Med, Dept Prevent Med & Publ Hlth, Tokyo, Japan

[22] Tokyo Womens Med Univ, Sch Med, Dept Publ Hlth, Tokyo, Japan

[23] Univ Auckland, Sch Populat Hlth, Auckland 1, New Zealand

[24] Univ Western Australia, Sch Populat Hlth, Perth, WA 6009, Australia

[25] Massey Univ, Ctr Publ Hlth Res, Palmerston North, New Zealand

[26] Norwegian Radiat Protect Author, Osteras, Oesteraas, Norway

[27] Canc Registry Norway, Oslo, Norway

[28] Norwegian Armed Forces, Sessvollmoen, Norway

[29] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[30] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[31] Univ Leeds, Ctr Biostat & Epidemiol, Leeds, W Yorkshire, England

[32] Univ Warwick, Hlth Sci Res Inst, Coventry CV4 7AL, W Midlands, England

[33] Inst Canc Res, Sutton, Surrey, England

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2010年 / 39卷 / 03期

基金：

加拿大健康研究院;

关键词：

Brain tumours; mobile phones; radiofrequency fields; PHONE USE; CELLULAR TELEPHONES; NONDIFFERENTIAL MISCLASSIFICATION; CORDLESS TELEPHONES; POOLED ANALYSIS; SELECTION BIAS; CANCER-RISK; EXPOSURE; POPULATION; MENINGIOMA;

D O I：

10.1093/ije/dyq079

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Methods An interview-based case-control study with 2708 glioma and 2409 meningioma cases and matched controls was conducted in 13 countries using a common protocol. Results A reduced odds ratio (OR) related to ever having been a regular mobile phone user was seen for glioma [OR 0.81; 95% confidence interval (CI) 0.70-0.94] and meningioma (OR 0.79; 95% CI 0.68-0.91), possibly reflecting participation bias or other methodological limitations. No elevated OR was observed >= 10 years after first phone use (glioma: OR 0.98; 95% CI 0.76-1.26; meningioma: OR 0.83; 95% CI 0.61-1.14). ORs were < 1.0 for all deciles of lifetime number of phone calls and nine deciles of cumulative call time. In the 10th decile of recalled cumulative call time, >= 1640 h, the OR was 1.40 (95% CI 1.03-1.89) for glioma, and 1.15 (95% CI 0.81-1.62) for meningioma; but there are implausible values of reported use in this group. ORs for glioma tended to be greater in the temporal lobe than in other lobes of the brain, but the CIs around the lobe-specific estimates were wide. ORs for glioma tended to be greater in subjects who reported usual phone use on the same side of the head as their tumour than on the opposite side. Conclusions Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible effects of long-term heavy use of mobile phones require further investigation.

引用

页码：675 / 694

页数：20

共 43 条

[1] Epidemiologic Evidence on Mobile Phones and Tumor Risk A Review [J].

Ahlbom, Anders ;

Feychting, Maria ;

Green, Adele ;

Kheifets, Leeka ;

Savitz, David A. ;

Swerdlow, Anthony J. .

EPIDEMIOLOGY, 2009, 20 (05) :639-652

[2]

[Anonymous], HLTH EFF EMF

[3] Brain tumors and salivary gland cancers among cellular telephone users [J].

Auvinen, A ;

Hietanen, M ;

Luukkonen, R ;

Koskela, RS .

EPIDEMIOLOGY, 2002, 13 (03) :356-359

[4]

BERNHARDT JH, 1997, P INT SEM BIOL EFF R

[5] EFFECT OF NONDIFFERENTIAL MISCLASSIFICATION ON ESTIMATES OF ODDS RATIOS WITH MULTIPLE LEVELS OF EXPOSURE [J].

BIRKETT, NJ .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 136 (03) :356-362

[6]

BRENNER H, 1994, EPIDEMIOLOGY, V5, P510

[7]

Breslow N.E., 1980, IARC SCI PUBLICATION, V32, P335

[8] International case-control study of adult brain, head and neck tumours: Results of the feasibility study [J].

Cardis, E ;

Kilkenny, M .

RADIATION PROTECTION DOSIMETRY, 1999, 83 (1-2) :179-183

[9] Distribution of RF energy emitted by mobile phones in anatomical structures of the brain [J].

Cardis, E. ;

Deltour, I. ;

Mann, S. ;

Moissonnier, M. ;

Taki, M. ;

Varsier, N. ;

Wake, K. ;

Wiart, J. .

PHYSICS IN MEDICINE AND BIOLOGY, 2008, 53 (11) :2771-2783

[10]

CARDIS E, 1999, IARC INTERNAL REPORT

← 1 2 3 4 5 →