Adolescents' and Parents' Attitudes Toward Adolescent Clinical Trial Participation: Changes Over One Year

被引：3

作者：

Tsevat, Rebecca K. ^{[1
]}

Breitkopf, Carmen Radecki ^{[4
]}

Landers, Sara E. ^{[2
]}

de Roche, Ariel M. ^{[2
]}

Mauro, Christine ^{[5
]}

Ipp, Lisa S. ^{[6
,7
]}

Catallozzi, Marina ^{[2
,5
,6
]}

Rosenthal, Susan L. ^{[2
,3
,6
]}

机构：

[1] Columbia Univ, Vagelos Coll Phys & Surg, 622 West 168th St,PH 17th Floor,Room 102A, New York, NY 10032 USA

[2] Columbia Univ, Vagelos Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA

[3] Columbia Univ, Vagelos Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA

[4] Mayo Clin, Dept Hlth Serv Res, Rochester, MN USA

[5] Columbia Univ, Mailman Sch Publ Hlth, New York, NY 10032 USA

[6] NewYork Presbyterian Hosp, New York, NY USA

[7] Weill Cornell Med Coll, New York, NY USA

来源：

JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS | 2018年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

adolescent health; clinical trials; decision-making; parental influence; reproductive health; WILLINGNESS;

D O I：

10.1177/1556264618790889

中图分类号：

B82 [伦理学（道德学）];

学科分类号：

摘要：

Little is known about how adolescents' and parents' thoughts about participation in clinical trials change over time. In this study, adolescent (14-17 years)-parent dyads were asked about willingness to participate in a hypothetical reproductive health study. A year later, they were asked how their thoughts about the study had changed. Qualitative responses were coded and analyzed using framework analysis. Thirty-two percent of adolescents and 18% of parents reported changes in thoughts; reasons included general changes in perception, clearer understanding, new knowledge or experiences, increased maturity/age of adolescents, and changes in participants independent of the study. Adolescents and parents may benefit from learning about studies multiple times, and investigators should account for development and new experiences to optimize adolescent research enrollment.

引用

页码：383 / 390

页数：8

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