Lipid metabolism and lipid signals in aging and longevity

被引：145
作者：
Mutlu, Ayse Sena [1 ]
Duffy, Jonathon [2 ]
Wang, Meng C. [1 ,2 ,3 ,4 ]
机构：
[1] Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA
[2] Baylor Coll Med, Dev Biol Grad Program, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA
来源：
DEVELOPMENTAL CELL | 2021年 / 56卷 / 10期
关键词：
GLUCAGON-LIKE PEPTIDE-1; OXIDATIVE STRESS-RESPONSE; FATTY-ACID-COMPOSITION; ELEGANS LIFE-SPAN; APOLIPOPROTEIN-D; GENE-EXPRESSION; C-ELEGANS; REGULATE LONGEVITY; COUPLED RECEPTORS; MAMMALIAN TARGET;
D O I：
10.1016/j.devcel.2021.03.034
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series of genetic pathways have been discovered to regulate lifespan in model organisms. Interestingly, many of these regulatory pathways are linked to lipid metabolism and lipid signaling. Lipid metabolic enzymes undergo significant changes during aging and are regulated by different longevity pathways. Lipids also actively modulate lifespan and health span as signaling molecules. In this review, we summarize recent insights into the roles of lipid metabolism and lipid signaling in aging and discuss lipid-related interventions in promoting longevity.
引用
收藏
页码：1394 / 1407
页数：14
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