Insect proteins as a potential source of antimicrobial peptides in livestock production. A review

被引:128
作者
Jozefiak, A. [1 ]
Engberg, R. M. [2 ]
机构
[1] Poznan Univ Life Sci, Inst Vet Sci, Wolynska 35, PL-60637 Poznan, Poland
[2] Aarhus Univ, Dept Anim Sci, Blichers Alle 20, DK-8830 Tjele, Denmark
来源
JOURNAL OF ANIMAL AND FEED SCIENCES | 2017年 / 26卷 / 02期
关键词
insect AMPs; antimicrobial activity; defensins; bacterial resistance; dietary supplementation; livestock production; TOTAL TRACT DIGESTIBILITY; BLACK SOLDIER FLY; GROWTH-PERFORMANCE; INTESTINAL MORPHOLOGY; DIETARY SUPPLEMENTATION; ANTIBACTERIAL ACTIVITY; IMMUNE FUNCTION; HOST-DEFENSE; RESISTANCE; LARVAE;
D O I
10.22358/jafs/69998/2017
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Together with the extraction of first insect antimicrobial protein (AMP) from the pupae of the giant silk moths Hyalophora cecropia the antibacterial activity of insects was observed for the first time in 1980. Practically, AMPs are small, cationic proteins that exhibit activity against bacteria, fungi as well as certain parasites and viruses. It is known that in addition to their antimicrobial effect, they boost host specific innate immune responses and exert selective immunomodulatory effects involved in angiogenesis and wound healing. More than 1,500 proteins with antimicrobial activity have been identified in different organisms, including plants, fungi, bacteria and animals. Insects are a primary source of AMPs which are considered as not resulting in the development of natural bacterial resistance. In general, they are characterized as heat-stable with no adverse effects on eukaryotic cells. These characteristics contribute to the potential use of these proteins in human and veterinary medicine and in animal nutrition. Depending on their mode of action, insect AMPs may be applied as single peptides, as a complex of different AMPs and as an active fraction of insect proteins in the nutrition of different livestock. The great potential for the use of AMPs in animal production is primarily associated with the growing problem of antibiotics resistance, which has triggered the search for alternatives to antibiotics in livestock production. The review presents the current knowledge of insect AMPs, their chemical structure and mode of action with focus on their potential use in agriculture and livestock production.
引用
收藏
页码:87 / 99
页数:13
相关论文
共 83 条
[71]   Effects of the lactoferrin (LF) on the growth performance, intestinal microflora and morphology of weanling pigs [J].
Wang, Yi-Zhen ;
Shan, Ti-Zhong ;
Xu, Zi-Rong ;
Feng, Jie ;
Wang, Zhong-Qiang .
ANIMAL FEED SCIENCE AND TECHNOLOGY, 2007, 135 (3-4) :263-272
[72]   Dose-response effects of an antimicrobial peptide, a cecropin hybrid, on growth performance, nutrient utilisation, bacterial counts in the digesta and intestinal morphology in broilers [J].
Wen, Liu-Fa ;
He, Jian-Guo .
BRITISH JOURNAL OF NUTRITION, 2012, 108 (10) :1756-1763
[73]  
Wiesner J, 2011, BIOL INSPIR SYST, V2, P29, DOI 10.1007/978-90-481-9641-8_3
[74]   Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli [J].
Wu, Shudan ;
Zhang, Fengrui ;
Huang, Zhimin ;
Liu, Hong ;
Xie, Chunyuan ;
Zhang, Jiang ;
Thacker, Philip A. ;
Qiao, Shiyan .
PEPTIDES, 2012, 35 (02) :225-230
[75]   Metabolic profiles in the response to supplementation with composite antimicrobial peptides in piglets challenged with deoxynivalenol [J].
Xiao, H. ;
Wu, M. M. ;
Shao, F. Y. ;
Tan, B. E. ;
Li, T. J. ;
Ren, W. K. ;
Yin, J. ;
Wang, J. ;
He, Q. H. ;
Yin, Y. L. ;
Hou, Y. Q. .
JOURNAL OF ANIMAL SCIENCE, 2015, 93 (03) :1114-1123
[76]   Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function [J].
Xiao, H. ;
Tan, B. E. ;
Wu, M. M. ;
Yin, Y. L. ;
Li, T. J. ;
Yuan, D. X. ;
Li, L. .
JOURNAL OF ANIMAL SCIENCE, 2013, 91 (10) :4750-4756
[77]   Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: I. Growth performance, immune function, and antioxidation capacity [J].
Xiao, H. ;
Wu, M. M. ;
Tan, B. E. ;
Yin, Y. L. ;
Li, T. J. ;
Xiao, D. F. ;
Li, L. .
JOURNAL OF ANIMAL SCIENCE, 2013, 91 (10) :4772-4780
[78]   The application of antimicrobial peptides as growth and health promoters for swine [J].
Xiao, Hao ;
Shao, Fangyuan ;
Wu, Miaomiao ;
Ren, Wenkai ;
Xiong, Xia ;
Tan, Bie ;
Yin, Yulong .
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2015, 6
[79]   Effects of antimicrobial peptides in nursery diets on growth performance of pigs reared on five different farms [J].
Xiong, X. ;
Yang, H. S. ;
Li, L. ;
Wang, Y. F. ;
Huang, R. L. ;
Li, F. N. ;
Wang, S. P. ;
Qiu, W. .
LIVESTOCK SCIENCE, 2014, 167 :206-210
[80]   Insect antimicrobial peptides and their applications [J].
Yi, Hui-Yu ;
Chowdhury, Munmun ;
Huang, Ya-Dong ;
Yu, Xiao-Qiang .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 98 (13) :5807-5822