Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

被引：10

作者：

Boulinguiez, Alexis ^{[1
]}

Staels, Bart ^{[1
]}

Duez, Helene ^{[1
]}

Lancel, Steve ^{[1
]}

机构：

[1] Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,EGID U1011, F-59000 Lille, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2017年 / 1862卷 / 09期

关键词：

Mitochondria; Endoplasmic reticulum; Insulin resistance; Skeletal muscle; Lipid; ACTIVATED-RECEPTOR-GAMMA; UNFOLDED PROTEIN RESPONSE; TYROSINE-PHOSPHATASE; 1B; INDUCED ER STRESS; IN-VIVO; WEIGHT-LOSS; OXIDATIVE STRESS; CERAMIDE ACCUMULATION; CHEMICAL CHAPERONES; SIGNALING PATHWAYS;

D O I：

10.1016/j.bbalip.2017.05.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity and its associated metabolic disorders represent a major health burden, with economic and social consequences. Although adapted lifestyle and bariatric surgery are effective in reducing body weight, obesity prevalence is still rising. Obese individuals often become insulin-resistant. Obesity impacts on insulin responsive organs, such as the liver, adipose tissue and skeletal muscle, and increases the risk of cardiovascular diseases, type 2 diabetes and cancer. In this review, we discuss the effects of obesity and insulin resistance on skeletal muscle, an important organ for the control of postprandial glucose. The roles of mitochondria and the endoplasmic reticulum in insulin signaling are highlighted and potential innovative research and treatment perspectives are proposed.

引用

页码：901 / 916

页数：16

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