Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to-child HIV transmission

被引：52

作者：

Kuhn, Louise ^{[1
,2
]}

Aldrovandi, Grace M. ^{[3
]}

Sinkala, Moses ^{[4
]}

Kankasa, Chipepo ^{[5
]}

Mwiya, Mwiya ^{[5
]}

Thea, Donald M. ^{[6
]}

机构：

[1] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

[2] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10027 USA

[3] Univ So Calif, Childrens Hosp Los Angeles, Dept Pediat, Los Angeles, CA USA

[4] Univ Zambia, Catholic Med Mission Board, Lusaka, Zambia

[5] Univ Zambia, Univ Teaching Hosp, Lusaka, Zambia

[6] Boston Univ, Sch Publ Hlth, Ctr Int Hlth & Dev, Boston, MA USA

来源：

AIDS | 2010年 / 24卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1097/QAD.0b013e3283394f5b

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We reviewed the potential impact of new WHO criteria for antiretroviral therapy using data from 1025 HIV-infected women and infants followed for 24 months in Lusaka, Zambia. The new criteria require initiating therapy among 68% of pregnant women and, if fully effective, would prevent 92% of maternal deaths and 88% of perinatal and postnatal infections. Using CD4 cell count below 350 cells/ml, irrespective of clinical stage, is more efficient and stricter CD4 cutoffs would be counter productive.

引用

页码：1374 / 1377

页数：4

共 6 条

[1]

[Anonymous], 2009, ANT THER HIV INF AD

[2] Universal Antiretroviral Therapy for Pregnant and Breast-Feeding HIV-1-Infected Women: Towards the Elimination of Mother-to-Child Transmission of HIV-1 in Resource-Limited Settings [J].

Becquet, Renaud ;

Ekouevi, Didier K. ;

Arrive, Elise ;

Stringer, Jeffrey S. A. ;

Meda, Nicolas ;

Chaix, Marie-Laure ;

Treluyer, Jean-Marc ;

Leroy, Valeriane ;

Rouzioux, Christine ;

Blanche, Stephane ;

Dabis, Francois .

CLINICAL INFECTIOUS DISEASES, 2009, 49 (12) :1936-1945

[3] Comparison of CD4 Cell Count, Viral Load, and Other Markers for the Prediction of Mortality among HIV-1-Infected Kenyan Pregnant Women [J].

Brown, Elizabeth R. ;

Otieno, Phelgona ;

Mbori-Ngacha, Dorothy A. ;

Farquhar, Carey ;

Obimbo, Elizabeth M. ;

Nduati, Ruth ;

Overbaugh, Julie ;

John-Stewart, Grace C. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (09) :1292-1300

[4]

DUGAN K, 2009, 1 INT WORKSH HIV PED

[5] Effects of early, abrupt weaning on HIV-free survival of children in Zambia [J].

Kuhn, Louise ;

Aldrovandi, Grace M. ;

Sinkala, Moses ;

Kankasa, Chipepo ;

Semrau, Katherine ;

Mwiya, Mwiya ;

Kasonde, Prisca ;

Scott, Nancy ;

Vwalika, Cheswa ;

Walter, Jan ;

Bulterys, Marc ;

Tsai, Wei-Yann ;

Thea, Donald M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (02) :130-141

[6] Postnatal HIV-1 Transmission after Cessation of Infant Extended Antiretroviral Prophylaxis and Effect of Maternal Highly Active Antiretroviral Therapy [J].

Taha, Taha E. ;

Kumwenda, Johnstone ;

Cole, Stephen R. ;

Hoover, Donald R. ;

Kafulafula, George ;

Fowler, Mary Glenn ;

Thigpen, Michael C. ;

Li, Qing ;

Kumwenda, Newton I. ;

Mofenson, Lynne .

JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (10) :1490-1497

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