Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches

被引：177
作者：
Needham, Merrilee [1 ]
Mastaglia, Frank L. [1 ]
机构：
[1] Univ Western Australia, Ctr Neuromuscular & Neurol Disorders, Queen Elizabeth II Med Ctr, Perth, WA 6009, Australia
来源：
LANCET NEUROLOGY | 2007年 / 6卷 / 07期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S1474-4422(07)70171-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Inclusion body myositis is the most common acquired muscle disease in older individuals, and its prevalence varies among countries and ethnic groups. The aetiology and pathogenesis of sporadic inclusion body myositis are still poorly understood; however genetic factors, ageing, and environmental triggers might all have a role. Unlike other inflammatory myopathies, sporadic inclusion body myositis causes slowly progressing muscular weakness and atrophy, it has a distinctive pattern of muscle involvement, and is unresponsive to conventional forms of immunotherapy. This review covers the clinical presentation, diagnosis, treatment, and the latest information on genetic susceptibility and pathogenesis of sporadic inclusion body myositis.
引用
收藏
页码：620 / 631
页数：12
相关论文
共 158 条
[71]   INCLUSION-BODY MYOSITIS PRESENTING WITH ISOLATED ERECTOR SPINAE PARESIS [J].
HUND, E ;
HECKL, R ;
GOEBEL, HH ;
MEINCK, HM .
NEUROLOGY, 1995, 45 (05) :993-994
[72]   Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle [J].
Jaworska-Wilczynska, M ;
Wilczynski, GM ;
Engel, WK ;
Strickland, DK ;
Weisgraber, KH ;
Askanas, V .
NEUROLOGY, 2002, 58 (03) :438-445
[73]   Transgenic mice over-expressing the C-99 fragment of βPP with an α-secretase site mutation develop a myopathy similar to human inclusion body myositis [J].
Jin, LW ;
Hearn, MG ;
Ogburn, CE ;
Dang, N ;
Nochlin, D ;
Ladiges, WC ;
Martin, GM .
AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (06) :1679-1686
[74]   Primary Sjogren's syndrome associated with inclusion body myositis [J].
Kanellopoulos, P ;
Baltoyiannis, C ;
Tzioufas, AG .
RHEUMATOLOGY, 2002, 41 (04) :440-444
[75]   EXPRESSION OF IMMUNOREACTIVE MAJOR HISTOCOMPATIBILITY COMPLEX PRODUCTS IN HUMAN SKELETAL-MUSCLES [J].
KARPATI, G ;
POULIOT, Y ;
CARPENTER, S .
ANNALS OF NEUROLOGY, 1988, 23 (01) :64-72
[76]   PM-Scl antibody positive systemic sclerosis associated with inclusion-body myositis [J].
Kim S. ;
Genth E. ;
Krieg T. ;
Hunzelmann N. .
Zeitschrift für Rheumatologie, 2005, 64 (7) :499-502
[77]   Genetically augmenting Aβ42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice [J].
Kitazawa, Masashi ;
Green, Kim N. ;
Caccamo, Antonella ;
LaFerla, Frank M. .
AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (06) :1986-1997
[78]  
Koffman BM, 1998, MUSCLE NERVE, V21, P115, DOI 10.1002/(SICI)1097-4598(199801)21:1<115::AID-MUS15>3.3.CO
[79]  
2-G
[80]   HLA allele distribution distinguishes sporadic inclusion body myositis from hereditary inclusion body myopathies [J].
Koffman, BM ;
Sivakumar, K ;
Simonis, T ;
Stroncek, D ;
Dalakas, MC .
JOURNAL OF NEUROIMMUNOLOGY, 1998, 84 (02) :139-142
3456789101112