AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease

被引：23

作者：

Li, Chunying ^{[1
]}

Keaney, John F., Jr. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01655 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 02期

关键词：

VASCULAR ENDOTHELIAL-CELLS; SIGNALING PATHWAY; OXIDATIVE STRESS; ANGIOTENSIN-II; MUSCLE-CELLS; IN-VIVO; C-ZETA; HEART; DYSFUNCTION; YEAST;

D O I：

10.1016/j.coph.2009.11.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

AMP-activated protein kinase (AMPK) was initially viewed as energy sensor and activated by increased intracellular concentrations of AMP following nutrient deprivation. Physiological or pathological stimuli that deplete cellular energy activate AMPK that coordinates a cellular program that limits further ATP depletion and promotes compensatory changes that maintain cellular ATP levels. Recent studies revealed novel roles of AMPK independent of energy status, thereby increasing our understanding of multi-functional roles of AMPK in cells important in pathogenesis of cardiovascular diseases. This enzyme represents an attractive therapeutic target for vascular disease treatment in the future.

引用

页码：111 / 115

页数：5

共 41 条

[1] COMPLEMENTATION OF SNF1, A MUTATION AFFECTING GLOBAL REGULATION OF CARBON METABOLISM IN YEAST, BY A PLANT PROTEIN-KINASE CDNA [J].

ALDERSON, A ;

SABELLI, PA ;

DICKINSON, JR ;

COLE, D ;

RICHARDSON, M ;

KREIS, M ;

SHEWRY, PR ;

HALFORD, NG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8602-8605

[2] Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome [J].

Buhl, ES ;

Jessen, N ;

Pold, R ;

Ledet, T ;

Flyvbjerg, A ;

Pedersen, SB ;

Pedersen, O ;

Schmitz, O ;

Lund, S .

DIABETES, 2002, 51 (07) :2199-2206

[3] The AMP-activated protein kinase cascade - a unifying system for energy control [J].

Carling, D .

TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (01) :18-24

[4]

CARLSON M, 1981, GENETICS, V98, P41

[5] A YEAST GENE THAT IS ESSENTIAL FOR RELEASE FROM GLUCOSE REPRESSION ENCODES A PROTEIN-KINASE [J].

CELENZA, JL ;

CARLSON, M .

SCIENCE, 1986, 233 (4769) :1175-1180

[6] STRUCTURE AND EXPRESSION OF THE SNF1 GENE OF SACCHAROMYCES-CEREVISIAE [J].

CELENZA, JL ;

CARLSON, M .

MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (01) :54-60

[7] RETRACTED: Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo (Retracted article. See vol. 294, pg. 10742, 2019) [J].

Choi, Hyoung Chul ;

Song, Ping ;

Xie, Zhonglin ;

Wu, Yong ;

Xu, Jian ;

Zhang, Miao ;

Dong, Yunzhou ;

Wang, Shuangxi ;

Lau, Kai ;

Zou, Ming-Hui .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (29) :20186-20197

[8] AMPKα1 regulates the antioxidant status of vascular endothelial cells [J].

Colombo, Sergio L. ;

Moncada, Salvador .

BIOCHEMICAL JOURNAL, 2009, 421 :163-169

[9] Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio [J].

Emerling, Brooke M. ;

Weinberg, Frank ;

Snyder, Colleen ;

Burgess, Zach ;

Mutlu, Goekhan M. ;

Viollet, Benoit ;

Budinger, G. R. Scott ;

Chandel, Navdeep S. .

FREE RADICAL BIOLOGY AND MEDICINE, 2009, 46 (10) :1386-1391

[10] Inhibition of Tumor Necrosis Factor α-Stimulated Monocyte Adhesion to Human Aortic Endothelial Cells by AMP-Activated Protein Kinase [J].

Ewart, Marie-Ann ;

Kohlhaas, Christine F. ;

Salt, Ian P. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (12) :2255-2257

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