Focally injected adenosine prevents seizures in the rat

被引：40

作者：

Anschel, DJ ^{[1
]}

Ortega, EL ^{[1
]}

Kraus, AC ^{[1
]}

Fisher, RS ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Stanford Comprehens Epilepsy Ctr, Dept Neurol, Stanford, CA 94305 USA

来源：

EXPERIMENTAL NEUROLOGY | 2004年 / 190卷 / 02期

关键词：

rat; seizure; prophylaxis; prevention; bicuculline; adenosine; intracerebral; intracranial; injection; epilepsy;

D O I：

10.1016/j.expneurol.2004.07.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prophylactic drug injection directly onto a seizure focus has the potential to improve seizure control with fewer side effects than is produced by systemic therapy. Using a dose-response model, we evaluated the effectiveness of adenosine application for focal seizure prophylaxis in 12 rats. Total spikes and electroencephalographic ictal events were reduced significantly by treatment with adenosine compared to control (P<0.0001). This study demonstrates effectiveness and feasibility in a model system using intracranial injection of adenosine to prevent epileptiform events. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：544 / 547

页数：4

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