Neurocognitive-neurological complications of liver transplantation: a review

被引：46
作者：
Campagna, Francesca [1 ]
Biancardi, A. [1 ]
Cillo, U. [2 ]
Gatta, A. [1 ]
Amodio, P. [1 ]
机构：
[1] Univ Padua, Dept Clin & Expt Med, I-35128 Padua, Italy
[2] Univ Padua, Dept Gen Surg & Organ Transplantat, I-35128 Padua, Italy
来源：
METABOLIC BRAIN DISEASE | 2010年 / 25卷 / 01期
关键词：
Neurological complications; Neurocognitive alterations; Quality of life; Hepatic encephalopathy; Liver transplantation; QUALITY-OF-LIFE; MINIMAL HEPATIC-ENCEPHALOPATHY; CEREBRAL-BLOOD-FLOW; POSTERIOR LEUKOENCEPHALOPATHY; ORGAN-TRANSPLANTATION; CIRRHOTIC-PATIENTS; COGNITIVE FUNCTION; CENTRAL PONTINE; NERVOUS-SYSTEM; CYCLOSPORINE-A;
D O I：
10.1007/s11011-010-9183-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neurological complications are common after liver transplantation (LT) and they are associated with a significant morbidity. Long-term effects of LT on cognitive and psychological outcomes are not clear. The objective of this study was to summarize the present knowledge on the neurological and cognitive complications of LT, resulting from a systematic review of the literature in the last 10 years. Several studies have investigated the incidence and the pathophysiology of neurological complications; in contrast, the knowledge of cognitive and psychological status after LT is poor. Currently, the effect of LT on mental performance is debated. Some studies have shown an improvement of cognitive function after OLTX and, at the same time, a persistence of different cognitive deficits. In addition, the quality of life (QoL) and the psychological status after LT seem to improve but LT recipients have significant deficiencies in most QoL domains. Consequently, future studies are necessary in order to investigate cognitive alterations and QoL in LT recipients.
引用
收藏
页码：115 / 124
页数：10
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