Effectiveness of Highly Active Antiretroviral Therapy (HAART) Used Concomitantly With Rifampicin in Patients with Tuberculosis and AIDS

被引:3
作者
Sant'Anna, Flavia Marinho
Velasque, Luciane
Costa, Marli Jane
Schmaltz, Carolina Arana
Morgado, Mariza Goncalves [2 ]
Lourenco, Maria Cristina [1 ]
Grinsztejn, Beatriz
Rolla, Valeria Cavalcanti [1 ]
机构
[1] Fundacao Oswaldo Cruz, Inst Pesquisa Clin Evandro Chagas, Bacteriol Lab, BR-21045900 Rio De Janeiro, Brazil
[2] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab AIDS & Imunol Mol, Dept Imunol, BR-21045900 Rio De Janeiro, Brazil
关键词
Tuberculosis; AIDS; HAART; rifampicin; effectiveness; HIV-INFECTED PATIENTS;
D O I
10.1590/S1413-86702009000500010
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
This study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) treatment naive and ARV experienced patients were compared. The effectiveness of HAART was defined as a VL < 80 copies/mL from month 4 to month 10 after TB treatment. One hundred and forty-two patients were included. Among these, 68 (47%) were treatment naive and 76 (53%) previously exposed. Odds ratio (OR) in naive patients treated with efavirenz (EFV) based regimen (n=42) compared to ritonavir/saquinavir (RTV/SQV) based regimen (n=26) was 8.0 (CI=1.67-38.35, p=0.008). OR from ARV experienced patients treated with RTV/SQV based regimen compared to EFV was 3.08 (CI=0.65-14.6, p=0.15), although with no statistical significance. Better effectiveness and tolerability were observed in antiretrovirals treatment naive patients using EFV based regimens. Although not statistically significant, a favorable virologic response and a better tolerability were observed in the ARV experienced patients group who received a RTV/SQV based regimen.
引用
收藏
页码:362 / 366
页数:5
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