Diacylglycerol-mediated insulin resistance

被引：394

作者：

Erion, Derek M. ^{[1
,2
]}

Shulman, Gerald I. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Internal Med, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Cellular & Mol Physiol, New Haven, CT USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 04期

关键词：

PROTEIN-KINASE-C; INDUCED HEPATIC STEATOSIS; MUSCLE GLYCOGEN-SYNTHESIS; SKELETAL-MUSCLE; FATTY-ACIDS; GLUCOSE-TRANSPORT; MITOCHONDRIAL DYSFUNCTION; ENERGY-EXPENDITURE; KNOCKOUT MICE; UP-REGULATION;

D O I：

10.1038/nm0410-400

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to explain insulin resistance, and, most recently, inflammation associated with alterations in adipocytokines has become the prevailing hypothesis. Here we discuss diacylglycerol-mediated insulin resistance as an alternative and unifying hypothesis to explain the most common forms of insulin resistance associated with obesity and type 2 diabetes mellitus, as well as lipodystrophy and aging.

引用

页码：400 / 402

页数：3

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