Cytoskeleton Remodeling and Oxidative Stress Description in Morphologic Changes of Chondrocyte in Kashin-Beck Disease

被引：8

作者：

Ma, Wei Juan ^{[1
]}

Guo, Xiong ^{[1
]}

Yu, Yue Xiang ^{[2
]}

Gao, Zong Qiang ^{[3
]}

机构：

[1] Xi An Jiao Tong Univ, Coll Publ Hlth, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China

[2] Shaanxi Prov Inst Endem Dis Control, Xian, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp 2, Xian 710061, Shaanxi, Peoples R China

来源：

ULTRASTRUCTURAL PATHOLOGY | 2014年 / 38卷 / 06期

关键词：

Kashin-Beck disease; mitochondria; endoplasmic reticulum; biological information; cytoskeleton; oxidative stress; MESSENGER-RNA; HNRNP-C; TRANSLATION; PROTEINS;

D O I：

10.3109/01913123.2014.950779

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

Kashin-Beck disease (KBD) is a kind of deformity disease involved in cytoskeleton and inner homeostasis regulation. The enrichment analysis of bioprocess, networks, and related disease set were performed. The development regulation, metabolic process, and apoptosis were important procession in KBD; it revealed the up-regulated process in removal of superoxide radicals, glycolysis and glucose catabolic process, regulation of cytoskeleton rearrangement and phagosome in antigen presentation. Morphological changes of KBD chondrocyte were investigated by transmission electronic microscopy compare with the normal one. The ultrastructure of KBD chondrocyte referred to oxidative stress and metabolic dysfunction has been found.

引用

页码：406 / 412

页数：7

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