Unprecedented 1,1′-carbonyldiimidazole-mediated amidation of unprotected α-amino acids in water

被引：15

作者：

Sharma, Rohit K. ^{[1
]}

Jain, Rahul ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Nagar 160062, Punjab, India

来源：

SYNLETT | 2007年 / 04期

关键词：

amidation; 1,1 '-carbonyldiimidazole (CDI); alpha-amino acids; amidation reaction in water;

D O I：

10.1055/s-2007-967965

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first amidation reaction of unprotected a-amino acids in water under neutral conditions with various aliphatic, aromatic and heteroaromatic amines in the presence of coupling reagent 1,1'-carbonyldiimidazole at ambient temperature is described.

引用

页码：603 / 606

页数：4

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