Iron catalyzed diastereoselective hydrogenation of chiral imines

被引：27
作者：
Brenna, D. [1 ]
Rossi, S. [1 ]
Cozzi, F. [1 ]
Benaglia, M. [1 ]
机构：
[1] Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 27期
关键词：
ASYMMETRIC TRANSFER HYDROGENATION; METAL-DIENE COMPLEXES; ENANTIOSELECTIVE HYDROGENATION; REDUCTIVE AMINATION; ORGANIC-SYNTHESIS; BRONSTED ACID; KETONES; CYCLOADDITIONS;
D O I：
10.1039/c7ob01123g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cyclopentadienone-based iron complexes were used for the first time to successfully catalyze the diastereoselective hydrogenation of enantiopure imines. Chiral amines, including valuable biologically active products, were obtained often as enantiomerically pure compounds. Computational studies helped to elucidate the chemical and stereochemical aspects of the iron-catalyzed reaction.
引用
收藏
页码：5685 / 5688
页数：4
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