Prognostic value of soluble cluster differentiation antigen 14 subtype and platelet activating factor in patients with septic shock

Objective: The aim of this study was to observe and evaluate differential diagnosis and the prognostic value of serum soluble cluster differentiation antigen 14 subtype (sCD14-ST) and platelet activating factor (PAF) in septic shock. Methods: From February 2015 to February 2017, 15 patients with septic shock, 20 patients with severe sepsis, and 30 patients with sepsis, in Jiaozhou People's Hospital, were enrolled in this study. In the same period, 30 healthy subjects were selected as the control group. Serum levels of sCD14-ST, PAF, procalcitonin (PCT), C reactive protein (CRP), and white blood cell count (WBC) were measured upon patient admission. Acute physiology and chronic health status II (APACHE-II) scores were also calculated. Differences in each indicator among those groups were compared. Correlation between sCD14-ST, PAF, and APACHE-II scores was analyzed. Receiver operating characteristic curve was used to compare values of various inflammatory markers in diagnosis of septic shock. Results: Levels of sCD14-ST, PAF, PCT, CRP, and WBC as well as scores of APACHE-II in patients with sepsis, severe sepsis, and septic shock were significantly higher than those in the healthy control group (all P<0.05). Levels of sCD14-ST and PAF in patients with septic shock were significantly higher than in patients with severe sepsis and sepsis (all P<0.05). Levels of sCD14-ST and PAF in patients with septic shock were positively correlated with APACHE-II scores. Multiple Logistic regression analysis showed that increase in APACHE-II scores, sCD14-ST, and PAF was an independent risk factor for death of patients with septic shock. Conclusion: sCD14-ST and PAF can be used as diagnostic indicators of septic shock and can monitor prognosis of sepsis.