Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities

被引:35
作者
Gong, Kai-Kai [1 ,2 ]
Tang, Xu-Li [3 ]
Liu, Yi-Sheng [1 ]
Li, Ping-Lin [2 ]
Li, Guo-Qiang [2 ]
机构
[1] Binzhou Med Univ Hosp, Dept Pharm, Yellow River Second Rd 661, Binzhou 256603, Peoples R China
[2] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Yushan Rd 5, Qingdao 266003, Peoples R China
[3] Ocean Univ China, Coll Chem & Chem Engn, Songling Rd 238, Qingdao 266100, Peoples R China
基金
中国国家自然科学基金;
关键词
sponge; Pericharax heteroraphis; 2-aminoimidazole alkaloids; cytotoxicities; anti-H1N1; activity; LEUCETTA-CHAGOSENSIS; CF; CHAGOSENSIS; CELL-LINES; ANTAGONIST; NAAMIDINE; RECEPTOR; ASSAY;
D O I
10.3390/molecules21020150
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on the marine sponge Pericharax heteroraphis collected from the South China Sea yielded one new imidazole alkaloid named naamidine J (1) along with four known ones (2-5). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed a central 2-aminoimidazole ring, substituted by one or two functionalized benzyl groups in some combination of the C4 and C5 positions. The cytotoxicities against selected HL-60, HeLa, A549 and K562 tumor cell lines and anti-H1N1 (Influenza a virus (IAV)) activity for the isolates were evaluated. Compounds 1 and 2 exhibited cytotoxicities against the K562 cell line with IC50 values of 11.3 and 9.4 M, respectively. Compound 5 exhibited weak anti-H1N1 (influenza a virus, IAV) activity with an inhibition ratio of 33%.
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页数:8
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