Effects of Exercise Training on Circulating High Molecular Weight Adiponectin and Adiponectin Oligomer Composition: a Randomized Controlled Trial

Aim: To determine the effects of exercise training on total and high molecular weight (HMW) adiponectin and adiponectin oligomeric distribution. Methods: A randomized parallel-design study (n = 53; 40 women and 13 men; age range, 32-65 years) was conducted at a fitness club between April 2006 and July 2007. Participants were randomly assigned to the exercise (n = 26) or control (n = 27) group and received exercise training for 70 min 2 times per week for 12 weeks and exercise advice at the baseline, respectively. The primary outcomes were changes in total adiponectin, HMW adiponectin and percentage of HMW adiponectin. Results: Muscle strength) improved in the exercise group but remained stable in the control group. Body weight and BMI were not modified by exercise training. After 12 weeks, there were no differences between groups in total adiponectin levels, HMW adiponectin levels, or percentage of HMW adiponectin. Conclusion: In the absence of weight loss, twice-weekly exercise training does not change HMW adiponectin levels or the adiponectin oligomer composition.