Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment

被引：20

作者：

Kogure, Takayuki ^{[1
]}

Ueno, Yoshiyuki ^{[1
]}

Fukushima, Koji ^{[1
]}

Nagasaki, Futoshi ^{[1
]}

Inoue, Jun ^{[1
]}

Kakazu, Eiji ^{[1
]}

Matsuda, Yasunori ^{[1
]}

Kido, Osamu ^{[1
]}

Nakagome, Yu ^{[1
]}

Kimura, Osamu ^{[1
]}

Obara, Noriyuki ^{[1
]}

Wakui, Yuta ^{[1
]}

Iwasaki, Takao ^{[1
]}

Shimosegawa, Tooru ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 32期

关键词：

autoimmune hepatitis; interferon; ribavirin; hepatitis C virus; anti-viral therapyA; acute liver failure;

D O I：

10.3748/wjg.v13.i32.4394

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. (c) 2007 WJG. All rights reserved.

引用

页码：4394 / 4397

页数：4

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