Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment

被引：20
|
作者：
Kogure, Takayuki [1 ]
Ueno, Yoshiyuki [1 ]
Fukushima, Koji [1 ]
Nagasaki, Futoshi [1 ]
Inoue, Jun [1 ]
Kakazu, Eiji [1 ]
Matsuda, Yasunori [1 ]
Kido, Osamu [1 ]
Nakagome, Yu [1 ]
Kimura, Osamu [1 ]
Obara, Noriyuki [1 ]
Wakui, Yuta [1 ]
Iwasaki, Takao [1 ]
Shimosegawa, Tooru [1 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Aoba Ku, Sendai, Miyagi 9808574, Japan
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 32期
关键词：
autoimmune hepatitis; interferon; ribavirin; hepatitis C virus; anti-viral therapyA; acute liver failure;
D O I：
10.3748/wjg.v13.i32.4394
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. (c) 2007 WJG. All rights reserved.
引用
收藏
页码：4394 / 4397
页数：4
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