Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment

被引：20
|
作者：
Kogure, Takayuki [1 ]
Ueno, Yoshiyuki [1 ]
Fukushima, Koji [1 ]
Nagasaki, Futoshi [1 ]
Inoue, Jun [1 ]
Kakazu, Eiji [1 ]
Matsuda, Yasunori [1 ]
Kido, Osamu [1 ]
Nakagome, Yu [1 ]
Kimura, Osamu [1 ]
Obara, Noriyuki [1 ]
Wakui, Yuta [1 ]
Iwasaki, Takao [1 ]
Shimosegawa, Tooru [1 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Aoba Ku, Sendai, Miyagi 9808574, Japan
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 32期
关键词：
autoimmune hepatitis; interferon; ribavirin; hepatitis C virus; anti-viral therapyA; acute liver failure;
D O I：
10.3748/wjg.v13.i32.4394
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin, and her HCV-RNA became negative at wk 12, but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. (c) 2007 WJG. All rights reserved.
引用
收藏
页码：4394 / 4397
页数：4
相关论文
共 50 条
  • [1] Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment
    Takayuki Kogure
    Yoshiyuki Ueno
    Koji Fukushima
    Futoshi Nagasaki
    Jun Inoue
    Eiji Kakazu
    Yasunori Matsuda
    Osamu Kido
    Yu Nakagome
    Osamu Kimura
    Noriyuki Obara
    Yuta Wakui
    Takao Iwasaki
    Tooru Shimosegawa
    World Journal of Gastroenterology, 2007, (32) : 4394 - 4397
  • [2] Autoimmune hepatitis, 2 years after successful peg-interferon-alpha 2b plus ribavirin treatment in a patient with chronic hepatitis C
    Petropoulou, K. G.
    Dourakis, S. P.
    Delladetsima, J.
    Archimandritis, A. J.
    ANNALS OF GASTROENTEROLOGY, 2010, 23 (02): : 142 - 145
  • [3] Treatment with peg-interferon-alpha of patients with chronic hepatitis C
    Barbakadze, GG
    Pipiya, GV
    Kamkamidze, GK
    TERAPEVTICHESKII ARKHIV, 2005, 77 (02) : 73 - 75
  • [4] Late onset autoimmune thrombocytopenia associated with pegylated interferon-α-2b plus ribavirin treatment for chronic hepatitis C
    Elefsiniotis, IS
    Pantazis, KD
    Fotos, NV
    Moulakakis, A
    Mavrogiannis, C
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2006, 21 (03) : 622 - 623
  • [5] Pegylated interferon α-2b plus ribavirin for older patients with chronic hepatitis C
    Mosaburo Kainuma
    Norihiro Furusyo
    Eiji Kajiwara
    Kazuhiro Takahashi
    Hideyuki Nomura
    Yuichi Tanabe
    Takeaki Satoh
    Toshihiro Maruyama
    Makoto Nakamuta
    Kazuhiro Kotoh
    Koichi Azuma
    Junya Shimono
    Shinji Shimoda
    Jun Hayashi
    World Journal of Gastroenterology, 2010, 16 (35) : 4400 - 4409
  • [6] Pegylated interferon α-2b plus ribavirin for older patients with chronic hepatitis C
    Kainuma, Mosaburo
    Furusyo, Norihiro
    Kajiwara, Eiji
    Takahashi, Kazuhiro
    Nomura, Hideyuki
    Tanabe, Yuichi
    Satoh, Takeaki
    Maruyama, Toshihiro
    Nakamuta, Makoto
    Kotoh, Kazuhiro
    Azuma, Koichi
    Shimono, Junya
    Shimoda, Shinji
    Hayashi, Jun
    WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (35) : 4400 - 4409
  • [7] Pegylated interferon α2b plus ribavirin for the treatment of chronic hepatitis C in HIV-infected patients
    Moreno, L
    Quereda, C
    Moreno, A
    Perez-Elías, MJ
    Antela, A
    Casado, JL
    Dronda, F
    Mateos, ML
    Bárcena, R
    Moreno, S
    AIDS, 2004, 18 (01) : 67 - 73
  • [8] Investigation of hyperuricemia during pegylated-interferon-α2b plus ribavirin combination therapy in patients with chronic hepatitis C
    Yamashita, Naoki
    Enjoji, Munechika
    Kotoh, Kazuhiro
    Kato, Masaki
    Ueda, Akihiro
    Horikawa, Yuki
    Tajiri, Hirotaka
    Higuchi, Nobito
    Kinukawa, Naoko
    Nakamuta, Makoto
    Takayanagi, Ryoichi
    JOURNAL OF DIGESTIVE DISEASES, 2008, 9 (01) : 27 - 31
  • [9] Bilateral AION after the combined therapy of hepatitis C with PEG-interferon α2B and ribavirin
    Kirchhoff, A
    Kirchhoff, U
    Lafrenz, M
    Guthoff, R
    KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 2004, 221 (09) : 791 - 793
  • [10] Effect of treatment with interferon α-2b and ribavirin in patients infected with genotype 2 hepatitis C virus
    Nagase, Yoshihiko
    Yotsuyanagi, Hiroshi
    Okuse, Chiaki
    Yasuda, Kiyomi
    Kato, Tomohiro
    Koike, Kazuhiko
    Suzuki, Michihiro
    Nishioka, Kusuki
    Iino, Shiro
    Itoh, Fumio
    HEPATOLOGY RESEARCH, 2008, 38 (03) : 252 - 258
12345