Genetic factors in type 2 diabetes: The end of the beginning?

被引：205

作者：

O'Rahilly, S ^{[1
]}

Barroso, I

Wareham, NJ

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England

[2] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

[3] MRC, Epidemiol Unit, Elsie Widdowson Lab, Cambridge CB1 9NL, England

来源：

SCIENCE | 2005年 / 307卷 / 5708期

关键词：

D O I：

10.1126/science.1104346

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intensive search for genetic variants that predispose to type 2 diabetes was launched with optimism, but progress has been slower than was hoped. Even so, major advances have been made in the understanding of monogenic forms of the disease which together represent a substantial health burden, and a few common gene variants that influence susceptibility have now been unequivocally identified. Armed with a better understanding of the tools needed to detect such genes, it seems inevitable that the rate of progress will increase and the relevance of genetic information to the diagnosis, treatment, and prevention of diabetes will become increasingly tangible.

引用

页码：370 / 373

页数：4

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