Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview

被引：37

作者：

Li, Kaijun ^{[1
]}

Ma, Chao ^{[1
]}

Li, Haoyu ^{[2
]}

Dev, Sooranna ^{[3
]}

He, JianFeng ^{[1
]}

Qu, Xiaosheng ^{[4
]}

机构：

[1] Guangxi Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Guangxi, Peoples R China

[2] Guangxi Univ Chinese Med China, Grad Sch, Guangxi, Peoples R China

[3] Chelsea & Westminster Hosp, Imperial Coll London, Dept Surg & Canc, 369 Fulham Rd, London SW10 9NH, England

[4] Natl Engn Lab Southwest Endangered Med Resources, Guangxi Bot Garden Med Plants China, Guangxi, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2019年 / 19卷 / 31期

基金：

中国国家自然科学基金;

关键词：

Gynostemma; Herbals; Etiology; Pharmacological action; Molecular mechanisms; Fibrosis; NF-KAPPA-B; FATTY LIVER-DISEASE; MITOCHONDRIA-DEPENDENT PATHWAYS; GYPENOSIDES-INDUCED APOPTOSIS; ISCHEMIA-REPERFUSION INJURY; CELL-CYCLE ARREST; CANCER SAS CELLS; IN-VITRO; ENDOPLASMIC-RETICULUM; OXIDATIVE STRESS;

D O I：

10.2174/1568026619666191114104718

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and convenient natural herbal drugs for the treatment of many diseases for a long time, and Gyps have different oral bioavailability (OB) values and low ability to cross the blood-brain barrier (BBB). The effects of GpM and isolates on fibrosis, inflammation, oxidation, proliferation and migration are proved. GpM shows bidirectional regulation effect on proliferation, oxidation and apoptosis in tumor and non-tumor cells. GpM and its extractions can resist proliferation, activate oxidation and apoptosis in tumor cells and have opposite effects on non-tumor cells. We succinctly present some current views of medicinal value and potential therapeutic mechanisms of GpM and its derivatives.

引用

页码：2855 / 2867

页数：13

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