Advances in redox-responsive drug delivery systems of tumor microenvironment

被引：282
作者：
Guo, Xiaoshuang [1 ,2 ]
Cheng, Yuan [1 ,2 ]
Zhao, Xiaotian [1 ,2 ]
Luo, Yanli [3 ]
Chen, Jianjun [4 ]
Yuan, Wei-En [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Minist Educ, Engn Res Ctr Cell & Therapeut Antibody, 800 Dongchuan RD, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan RD, Shanghai 200240, Peoples R China
[3] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Pathol, 600 Yi Shan Rd, Shanghai 200233, Peoples R China
[4] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou, Guangdong, Peoples R China
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2018年 / 16卷
基金：
美国国家科学基金会;
关键词：
Redox-responsive; Drug delivery system; Antitumor; Disulfide bond; CROSS-LINKED MICELLES; MESOPOROUS SILICA NANOPARTICLES; BLOCK-COPOLYMER ASSEMBLIES; IN-VIVO EVALUATION; CANCER-THERAPY; BIOMEDICAL APPLICATIONS; INTRACELLULAR DELIVERY; CONTROLLED-RELEASE; VISIBLE-LIGHT; BREAST-CANCER;
D O I：
10.1186/s12951-018-0398-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
With the improvement of nanotechnology and nanomaterials, redox-responsive delivery systems have been studied extensively in some critical areas, especially in the field of biomedicine. The system constructed by redox-responsive delivery can be much stable when in circulation. In addition, redox-responsive vectors can respond to the high intracellular level of glutathione and release the loaded cargoes rapidly, only if they reach the site of tumor tissue or targeted cells. Moreover, redox-responsive delivery systems are often applied to significantly improve drug concentrations in targeted cells, increase the therapeutic efficiency and reduce side effects or toxicity of primary drugs. In this review, we focused on the structures and types of current redox-responsive delivery systems and provided a comprehensive overview of relevant researches, in which the disulfide bond containing delivery systems are of the utmost discussion.
引用
收藏
页数：10
相关论文
共 71 条
[1]   Enzyme-triggered nanomedicine: Drug release strategies in cancer therapy (Invited Review) [J].
Andresen, Thomas L. ;
Thompson, David H. ;
Kaasgaard, Thomas .
MOLECULAR MEMBRANE BIOLOGY, 2010, 27 (07) :353-363
[2]   Redox-optimized ROS balance: A unifying hypothesis [J].
Aon, M. A. ;
Cortassa, S. ;
O'Rourke, B. .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2010, 1797 (6-7) :865-877
[3]   Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy [J].
Asgharzadeh, Mohammad Reza ;
Barar, Jaleh ;
Pourseif, Mohammad M. ;
Eskandani, Morteza ;
Niya, Mojtaba Jafari ;
Mashayekhi, Mohammad Reza ;
Omidi, Yadollah .
BIOIMPACTS, 2017, 7 (02) :115-133
[4]   Reversible maleimide-thiol adducts yield glutathione-sensitive poly(ethylene glycol)-heparin hydrogels [J].
Baldwin, Aaron D. ;
Kiick, Kristi L. .
POLYMER CHEMISTRY, 2013, 4 (01) :133-143
[5]   Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy [J].
Barar, Jaleh ;
Omidi, Yadollah .
BIOIMPACTS, 2013, 3 (04) :149-162
[6]   Polythiolactone-Based Redox-Responsive Layers for the Reversible Release of Functional Molecules [J].
Belbekhouche, Sabrina ;
Reinicke, Stefan ;
Espeel, Pieter ;
Du Prez, Filip E. ;
Eloy, Pierre ;
Dupont-Gillain, Christine ;
Jonas, Alain M. ;
Demoustier-Champagne, Sophie ;
Glinel, Karine .
ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (24) :22457-22466
[7]   Selenoglutathione: Efficient oxidative protein folding by a diselenide [J].
Beld, Joris ;
Woycechowsky, Kenneth J. ;
Hilvert, Donald .
BIOCHEMISTRY, 2007, 46 (18) :5382-5390
[8]   Strategies to overcome the polycation dilemma in drug delivery [J].
Bernkop-Schnuerch, Andreas .
ADVANCED DRUG DELIVERY REVIEWS, 2018, 136 :62-72
[9]   Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment [J].
Chen, Binlong ;
Dai, Wenbing ;
He, Bing ;
Zhang, Hua ;
Wang, Xueqing ;
Wang, Yiguang ;
Zhang, Qiang .
THERANOSTICS, 2017, 7 (03) :538-558
[10]   Transferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery [J].
Chen, Xiaolu ;
Sun, Hui ;
Hu, Jun ;
Han, Xia ;
Liu, Honglai ;
Hu, Ying .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 152 :77-84
12345678