H3K27me3 demethylases alter HSP22 and HSP17.6C expression in response to recurring heat in Arabidopsis

被引：104

作者：

Yamaguchi, Nobutoshi ^{[1
,2
]}

Matsubara, Satoshi ^{[1
]}

Yoshimizu, Kaori ^{[1
]}

Seki, Motohide ^{[3
]}

Hamada, Kouta ^{[4
]}

Kamitani, Mari ^{[5
]}

Kurita, Yuko ^{[5
]}

Nomura, Yasuyuki ^{[5
]}

Nagashima, Kota ^{[1
]}

Inagaki, Soichi ^{[2
,6
]}

Suzuki, Takamasa ^{[7
]}

Gan, Eng-Seng ^{[8
]}

To, Taiko ^{[6
]}

Kakutani, Tetsuji ^{[6
,9
,10
]}

Nagano, Atsushi J. ^{[5
,9
]}

Satake, Akiko ^{[4
]}

Ito, Toshiro ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Sci & Technol, Div Biol Sci, Ikoma, Nara, Japan

[2] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol, Kawaguchi, Saitama, Japan

[3] Kyushu Univ, Fac Design, Minami Ku, Fukuoka, Japan

[4] Kyushu Univ, Fac Sci, Dept Biol, Nishi Ku, Fukuoka, Japan

[5] Ryukoku Univ, Fac Agr, Otsu, Shiga, Japan

[6] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, Tokyo, Japan

[7] Chubu Univ, Coll Biosci & Biotechnol, Dept Biol Chem, Kasugai, Aichi, Japan

[8] Natl Univ Singapore, Temasek Life Sci Lab, 1 Res Link, Singapore, Singapore

[9] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama, Japan

[10] Natl Inst Genet, Mishima, Shizuoka, Japan

来源：

NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

GENE-EXPRESSION; METHYLATION; STRESS; REF6; SEQUENCE; PROTEIN; MEMORY;

D O I：

10.1038/s41467-021-23766-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acclimation to high temperature increases plants' tolerance of subsequent lethal high temperatures. Although epigenetic regulation of plant gene expression is well studied, how plants maintain a memory of environmental changes over time remains unclear. Here, we show that JUMONJI (JMJ) proteins, demethylases involved in histone H3 lysine 27 trimethylation (H3K27me3), are necessary for Arabidopsis thaliana heat acclimation. Acclimation induces sustained H3K27me3 demethylation at HEAT SHOCK PROTEIN22 (HSP22) and HSP17.6C loci by JMJs, poising the HSP genes for subsequent activation. Upon sensing heat after a 3-day interval, JMJs directly reactivate these HSP genes. Finally, jmj mutants fail to maintain heat memory under fluctuating field temperature conditions. Our findings of an epigenetic memory mechanism involving histone demethylases may have implications for environmental adaptation of field plants. Acclimation to high temperature increases tolerance of heat shock in plants. Here the authors show that JUMONJI H3K27me3 demethylases are needed for heat acclimation in Arabidopsis and act at loci encoding HEAT SHOCK PROTEINS to facilitate induction upon heat stress.

引用

页数：16

共 61 条

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