The role of formins in human disease

被引：55

作者：

DeWard, Aaron D. ^{[1
]}

Eisenmann, Kathryn M. ^{[2
]}

Matheson, Stephen F. ^{[1
,3
]}

Alberts, Arthur S. ^{[1
]}

机构：

[1] Van Andel Res Inst, Lab Cell Struct & Signal Integrat, Grand Rapids, MI 49503 USA

[2] Univ Toledo, Dept Biochem & Canc Biol, Toledo, OH 43614 USA

[3] Calvin Coll, Grand Rapids, MI 49503 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2010年 / 1803卷 / 02期

关键词：

Formin; Actin; Microtubule; Rho GTPase; Non-syndromic deafness; Cancer; Myelodysplasia; Tumor suppression; Premature ovarian failure; Limb deformity; Metastasis; Immune response; Oncosome; Microvesicle; DIAPHANOUS-RELATED FORMIN; FOCAL ADHESION DYNAMICS; LIMB DEFORMITY GENE; SRC TYROSINE KINASE; T-CELL-ACTIVATION; ACTIN POLYMERIZATION; INTEGRIN ALPHA(IIB)BETA(3); REGULATES ACTIN; MIGRATING CELLS; EFFECTOR MDIA1;

D O I：

10.1016/j.bbamcr.2009.11.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：226 / 233

页数：8

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