Levobupivacaine A Review of its Use in Regional Anaesthesia and Pain Management

被引:34
作者
Sanford, Mark [1 ]
Keating, Gillian M. [1 ]
机构
[1] Adis, Auckland 0754, New Zealand
关键词
Levobupivacaine; regional anaesthesia; labour analgesia; postoperative pain management; pharmacodynamics; pharmacokinetics; therapeutic use; tolerability; RANDOMIZED CONTROLLED-TRIAL; INGUINAL-HERNIA REPAIR; INTRATHECAL LABOR ANALGESIA; EMERGENCY CESAREAN-SECTION; BRACHIAL-PLEXUS BLOCK; DAY-CASE ARTHROSCOPY; SCIATIC-NERVE BLOCK; LOWER-LIMB SURGERY; EPIDURAL ANALGESIA; RACEMIC BUPIVACAINE;
D O I
10.2165/11203250-000000000-00000
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Levobupivacaine (Chirocaine (R)) is a long-acting amide local anaesthetic that is effective when administered as an epidural, spinal, peripheral nerve or ocular block, or by topical application or local infiltration. In comparative trials, its clinical effects were not generally significantly different from those of bupivacaine or ropivacaine, although there was some variability in efficacy findings in different clinical populations. Levobupivacaine was generally well tolerated. Levobupivacaine provides effective anaesthesia and analgesia for a wide range of clinical populations and is a useful alternative to bupivacaine.
引用
收藏
页码:761 / 791
页数:31
相关论文
共 98 条
[1]   Comparison of 0.5% levobupivacaine, 0.5% bupivacaine, and 2% lidocaine for retrobulbar anesthesia in vitreoretinal surgery [J].
Aksu, Recep ;
Bicer, Cihangir ;
Ozkiris, Abdullah ;
Akin, Aynur ;
Bayram, Adnan ;
Boyaci, Adem .
EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2009, 19 (02) :280-284
[2]   Pharmacokinetics of 0.5% levobupivacaine following ilioinguinal-iliohypogastric nerve blockade in children [J].
Ala-Kokko, TI ;
Räihä, E ;
Karinen, J ;
Kiviluoma, K ;
Alahuhta, S .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2005, 49 (03) :397-400
[3]   Effect of presurgical local infiltration of levobupivacaine in the surgical field on postsurgical wound pain in laparoscopic gynecological surgery [J].
Alessandri, Franco ;
Lijoi, Davide ;
Mistrangelo, Emanuela ;
Nicoletti, Annamaria ;
Ragni, Nicola .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2006, 85 (07) :844-849
[4]   Epidural lidocaine-bicarbonate-adrenaline vs levobupivacaine for emergency Caesarean section: a randomised controlled trial [J].
Allam, J. ;
Malhotra, S. ;
Hemingway, C. ;
Yentis, S. M. .
ANAESTHESIA, 2008, 63 (03) :243-249
[5]   Plasma levels of levobupivacaine after combined posterior lumbar plexus and sciatic nerve blocks [J].
Altermatt, F ;
Cortínez, LI ;
Muñoz, H .
ANESTHESIA AND ANALGESIA, 2006, 102 (05) :1597-1597
[6]   Postoperative analgesia requirements at home after inguinal hernia repair:: effects of wound infiltration on postoperative pain [J].
Ausems, M. E. ;
Hulsewe, K. W. ;
Hooymans, P. M. ;
Hoofwijk, A. G. .
ANAESTHESIA, 2007, 62 (04) :325-331
[7]   Clinical effects and maternal and fetal plasma concentrations of 0.5% epidural levobupivacaine versus bupivacaine for cesarean delivery [J].
Bader, AM ;
Tsen, LC ;
Camann, WR ;
Nephew, E ;
Datta, S .
ANESTHESIOLOGY, 1999, 90 (06) :1596-1601
[8]   Low-dose epidural top up for emergency caesarean delivery: a randomised comparison of levobupivacaine versus lidocaine/epinephrine/fentanyl [J].
Balaji, P. ;
Dhillon, P. ;
Russell, I. F. .
INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 2009, 18 (04) :335-341
[9]   A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers [J].
Bardsley, H ;
Gristwood, R ;
Baker, H ;
Watson, N ;
Nimmo, W .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 46 (03) :245-249
[10]   Comparison of 0.25% levobupivacaine and 0.25% bupivacaine for posterior approach interscalene brachial plexus block [J].
Baskan, Semih ;
Taspinar, Vildan ;
Ozdogan, Levent ;
Gulsoy, Kemal Yetis ;
Erk, Gulcan ;
Dikmen, Bayazit ;
Gogus, Nermin .
JOURNAL OF ANESTHESIA, 2010, 24 (01) :38-42