Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates

被引：59
作者：
Ayers, JD
Lowary, TL
Morehouse, CB
Besra, GS
机构：
[1] Ohio State Univ, Dept Chem, Columbus, OH 43202 USA
[2] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(98)00049-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of arabinofuranosyl oligosaccharides found as constituent parts of the polysaccharide portion of the cell wall of Mycobacterium tuberculosis have been chemically synthesized. Screening of these oligosaccharides as substrates for arabinosyltransferases present in mycobacterial membrane preparations suggests that modified oligosaccharide analogs as small as disaccharides may be inhibitors of glycan biosynthesis. Such inhibitors would be of potential utility as lead compounds in the identification of new drugs for the treatment of mycobacterial infections. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：437 / 442
页数：6
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