Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats

被引:16
作者
Cao, Ying [1 ]
Liu, Chun [1 ]
Ling, Liming [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Sleep Med, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
Glossopharyngeal nerve; Long-term facilitation; Serotonin receptors; NMDA receptors; Respiratory control; Plasticity; CHRONIC INTERMITTENT HYPOXIA; GENIOGLOSSUS MUSCLE-ACTIVITY; NERVE-STIMULATION; UPPER AIRWAY; PROLONGED STIMULATION; GENOMIC CONSEQUENCES; VENTILATION; SLEEP; ACTIVATION; PLASTICITY;
D O I
10.1016/j.resp.2009.12.005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Although the glossopharyngeal nerve (IX) is mainly a sensory nerve, it innervates stylopharyngeus and some other pharyngeal muscles, whose excitations would likely improve upper airway patency since electrical IX stimulation increases pharyngeal airway size. As acute intermittent hypoxia (AIH) induces hypoglossal and genioglossal long-term facilitation (LTF), we hypothesized that AM induces glossopharyngeal LTF, which requires serotonin 5-HT2 and NMDA receptors. Integrated IX activity was recorded in anesthetized, vagotomized, paralyzed and ventilated rats before, during and after 5 episodes of 3-min isocapnic 12% O-2 with 3-min intervals of 50% O-2. Either saline, ketanserin (5-HT2 antagonist, 2 mg/kg) or MK-801 (NMDA antagonist, 0.2 mg/kg) was (i.v.) injected 30-60 min before AIH. Both phasic and tonic IX activities were persistently increased (both P < 0.05) after AM in vehicle, but not ketanserin or MK-801, rats. Hypoxic glossopharyngeal responses were minimally changed after either drug. These data suggest that AIH induces both phasic and tonic glossopharyngeal LTF, which requires activation of 5-HT2 and NMDA receptors. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:164 / 172
页数:9
相关论文
共 62 条
[1]   Long-term facilitation in obstructive sleep apnea patients during NREM sleep [J].
Aboubakr, SE ;
Taylor, A ;
Ford, R ;
Siddiqi, S ;
Badr, MS .
JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (06) :2751-2757
[2]  
Babcock MA, 1998, SLEEP, V21, P709
[3]   Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent [J].
Bach, KB ;
Mitchell, GS .
RESPIRATION PHYSIOLOGY, 1996, 104 (2-3) :251-260
[4]   Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons [J].
Bocchiaro, CM ;
Feldman, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (12) :4292-4295
[5]   INCREASED NORMOXIC VENTILATION INDUCED BY REPETITIVE HYPOXIA IN CONSCIOUS DOGS [J].
CAO, KY ;
ZWILLICH, CW ;
BERTHONJONES, M ;
SULLIVAN, CE .
JOURNAL OF APPLIED PHYSIOLOGY, 1992, 73 (05) :2083-2088
[6]  
CAO Y, 2007, AM J RESP CRIT CARE, V175, pA70
[7]   Long-term facilitation of genioglossus activity is present in normal humans during NREM sleep [J].
Chowdhuri, Susmita ;
Pierchala, Lisa ;
Aboubakr, Salah E. ;
Shkoukani, Mahdi ;
Badr, M. Safwan .
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2008, 160 (01) :65-75
[8]   Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat [J].
Dick, Thomas E. ;
Hsieh, Yee-Hsee ;
Wang, Ning ;
Prabhakar, Nanduri .
EXPERIMENTAL PHYSIOLOGY, 2007, 92 (01) :87-97
[9]   LONG-TERM FACILITATION OF INSPIRATORY INTERCOSTAL NERVE ACTIVITY FOLLOWING CAROTID-SINUS NERVE-STIMULATION IN CATS [J].
FREGOSI, RF ;
MITCHELL, GS .
JOURNAL OF PHYSIOLOGY-LONDON, 1994, 477 (03) :469-479
[10]   Episodic hypoxia induces long-term facilitation of neural drive to tongue protrudor and retractor muscles [J].
Fuller, DD .
JOURNAL OF APPLIED PHYSIOLOGY, 2005, 98 (05) :1761-1767