Advances in Detection Methods of β-Amyloid Protein

被引：11
|
作者：
Jiang Meng [1 ]
Wang Xiao-Ying [1 ]
Wang Xiao-Bing [2 ]
机构：
[1] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China
来源：
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2018年 / 46卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; beta-Amyloid; Detection method; Electrochemical biosensor; Review; ALZHEIMERS-DISEASE; ELECTROCHEMICAL DETECTION; SIGNAL AMPLIFICATION; GOLD NANOPARTICLES; 1-42; PEPTIDE; OLIGOMER; IMMUNOASSAY; IMMUNOSENSOR; DIAGNOSIS; BIOSENSOR;
D O I：
10.1016/S1872-2040(18)61107-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Alzheimer's disease (AD) is a neurodegenerative disease with unknown etiology. beta-amyloid protein (A beta) is one of the specific biomarkers of AD, and many clinical studies suggest that abnormal levels of A beta in blood, cerebrospinal fluid and brain tissue are closely related to the progression of AD. The analysis and evaluation of A beta are important for early detection, tracking, prevention, and treatment of AD. In this paper, the present situations of the commonly used detection methods of A beta at home and abroad were summarized and compared. Specifically, the latest application of new electrochemical biosensor in A beta detection was mainly described, and the summary of its future directions and the potential applications was given.
引用
收藏
页码：1339 / 1348
页数：10
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