Recreating the biological pacemaker

被引：8
作者：
Rosen, MR
Robinson, RB
Brink, P
Cohen, IS
机构：
[1] Columbia Univ, Dept Pharmacol, Ctr Mol Therapeut, New York, NY 10032 USA
[2] Columbia Univ, Dept Pediat, New York, NY 10032 USA
[3] SUNY Stony Brook, Inst Mol Cardiol, Dept Physiol, Stony Brook, NY 11794 USA
[4] SUNY Stony Brook, Inst Mol Cardiol, Dept Biophys, Stony Brook, NY 11794 USA
来源：
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY | 2004年 / 280A卷 / 02期
关键词：
pacemaker current; HCN channels; heart block; cardiac arrhythmias; sinoatrial node;
D O I：
10.1002/ar.a.20073
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
In recent years, several groups have reported a variety of. strategies for developing biological pacemakers whose ultimate function would be to supplement/replace electronic pacemakers. Strategies have included gene therapy using naked plasmids or viral vectors and cell therapy for which both adult human mesenchymal stem cells (hMSCs) and human embryonic stem cells have been employed. This article reviews the various approaches and summarizes our own research in which the pacemaker gene, HCN2, is administered via viral vector or in an hMSC platform to produce pacemaker function in the intact canine heart. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码：1046 / 1052
页数：7
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