Circular RNAs: The star molecules in cancer

被引：132
作者：
Liu, Jianhong [1 ,2 ]
Li, Dongpei [3 ]
Luo, Hui [1 ]
Zhu, Xiao [1 ,2 ]
机构：
[1] Guangdong Med Univ, Marine Biomed Res Inst, Southern Marine Sci & Engn Guangdong Lab Zhanjian, Zhanjiang 524023, Peoples R China
[2] Guangdong Med Univ, Affiliated Hosp, Canc Ctr, Zhanjiang 524023, Peoples R China
[3] Augusta Univ, Med Coll Georgia, Augusta, GA 30901 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2019年 / 70卷
基金：
中国国家自然科学基金;
关键词：
Cancer; circRNAs; Diagnosis; Molecular target; Sponge; Therapy; HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; CELL-GROWTH; EXPRESSION; PROLIFERATION; GENE; MIGRATION; INVASION; DATABASE; PROMOTES;
D O I：
10.1016/j.mam.2019.10.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a closed loop structure. These RNAs are produced by pre-mRNA through variable shear processing and are highly conserved. Such highly conserved molecules play an important role in biology, especially in cancer biology. With the development of experimental techniques such as circRNA microarray screening and high-throughput sequencing technologies, the mystery of circRNAs has gradually been unveiled and the values of function and application have gradually emerged. Among them, cancer-related circRNAs are the most eye-catching. Numerous studies have shown that some circRNAs were involved in the pathogenesis of cancer. This review systematically introduced the cancer-related circRNAs and their origin, formation mechanisms, functions, and applications in the diagnosis and treatment of sixteen kinds of tumors.
引用
收藏
页码：141 / 152
页数：12
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