Patent foramen ovale (PFO) is a common finding in patients with cryptogenic stroke. We report the transcatheter closure of patent foramen ovale in a 43 year old patient with stroke by ASD Occlusion System (ASDOS(R)). A PFO may be detected by both invasive and noninvasive techniques. Transoesophageal contrast echocardiography has a greater sensitivity compared to transthoracal echo in detecting a PFO. Predictive risk factors for further neurologic events in patients with PFO are a large degree of shunt by contrast echocardiography and atrial septal aneurysm. Possibly patients with PFO and risk factors for stroke recurrence will take advantage from transcatheter closure.