Reaction of hydrazonoyl halides 52: Synthesis and antimicrobial activity of some new pyrazolines and 1,3,4-thiadiazolines

被引:22
作者
Abdelhamid, Abdou O. [1 ]
Sayed, Abdelwahed R.
机构
[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12622, Egypt
[2] Beni Suef Univ, Fac Sci, Dept Chem, Bani Suwayf, Egypt
关键词
2,3-dihydro-1,3,4-thiadiazoles; arylazothiazoles; hydrazonoyl halides; pyrazolines;
D O I
10.1080/10426500701313938
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
[5-Substituted 2-(3-phenyl-5-substituted 2-pyrazolinyl)(1,3-thiazol-4-yl)] phenyldiazene and 2,3-dihydro-1,3,4-thiadiazoles were synthesized via reactions of hydrazonoyl halides with 5-substituted-3-phenyl-4,5-dihydropyrazole-1-carboximidothionic acid and {[2-2-{aza-2-((methylthioxomethyl)-amino]-vinyl} phenyl)1-azavinyl] amino} methylthiomethane-1-thione, respectively. All structures of the newly synthesized compounds were elucidated by elemental analysis, spectral data, X-ray single crystal, and alternative synthesis methods whenever possible. Some of the new compounds were tested towards bacteria. In general, all tested compounds were capable of a high inhibiting the growth of gram positive and gram negative.
引用
收藏
页码:1767 / 1777
页数:11
相关论文
共 39 条
[31]   Synthesis of some new thiazole, thiophene, and 2,3-dihydro-1,3,4-thiadiazole and pyrimidino[1,2-b]indazole derivatives [J].
Rateb, NM .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2005, 180 (10) :2361-2372
[32]   Synthesis and antimicrobial evaluation of some 1,3-thiazole, 1,3,4-thiadiazole, 1,2,4-triazole, and 1,2,4-triazolo[3,4-b][1,3,4]-thiadiazine derivatives including a 5-(benzofuran-2-yl)-1-phenylpyrazole moiety [J].
Abdel-Wahab, Bakr F. ;
Abdel-Aziz, Hatem A. ;
Ahmed, Essam M. .
MONATSHEFTE FUR CHEMIE, 2009, 140 (06) :601-605
[33]   Synthesis, Characterization, Antimicrobial Activity and Anticancer of Some New Pyrazolo[1,5-a]pyrimidines and Pyrazolo[5,1-c]1 2,4-triazines [J].
Hosny, Mona A. ;
Zaki, Yasser H. ;
Mokbel, Wafaa A. ;
Abdelhamid, Abdou O. .
MEDICINAL CHEMISTRY, 2020, 16 (06) :750-760
[34]   Synthesis and Antimicrobial Activity of Some New 5-Arylazothiazole, Pyrazolo[1,5-a] Pyrimidine, [1,2,4]Triazolo[4,3-a]Pyrimidine, and Pyrimido[1,2-a]Benzimidazole Derivatives Containing the Thiazole Moiety [J].
Abdelhamid, Abdou O. ;
Abdelall, Eman K. A. ;
Abdel-Riheem, Nadia A. ;
Ahmed, Sayed A. .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2010, 185 (04) :709-718
[35]   Synthesis and In Silico Study of Some New bis-[1,3,4]thiadiazolimines and bis-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease [J].
Gomha, Sobhi M. ;
Riyadh, Sayed M. ;
Abdellattif, Magda H. ;
Abolibda, Tariq Z. ;
Abdel-aziz, Hassan M. ;
Nayl, AbdElAziz A. ;
Elgohary, Alaa M. ;
Elfiky, Abdo A. .
CURRENT ISSUES IN MOLECULAR BIOLOGY, 2022, 44 (10) :4540-4556
[36]   Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives [J].
Gomha, Sobhi Mohamed ;
Hassaneen, Huwaida M. E. .
MOLECULES, 2011, 16 (08) :6549-6560
[37]   Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines [J].
Abdelhamid, Abdou O. ;
El Sayed, Ibrahim E. ;
Hussein, Mohamed Z. ;
Mangoud, Mangoud M. .
MOLECULES, 2016, 21 (08)
[38]   A Convenient Synthesis of Some New 1,3,4-Thiadiazoles, Thiazoles, Pyrazolo[1,5-a]pyrimidines, Pyrazolo[5,1-c]triazine, and Thieno[3,2-d]pyrimidines Containing 5-Bromobenzofuran Moiety [J].
Abdelhamid, Abdou O. ;
Fahmi, Abdelgawad A. ;
Baaiu, Basma S. .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (04) :1292-1303
[39]   Synthesis, reactions, and antimicrobial activity of some novel pyrazolo[3,4-d]pyrimidine, pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine, and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives [J].
Hassaneen, Hamdi M. ;
Saleh, Fatma M. ;
Abdallah, Tayseer A. ;
Mohamed, Yasmin Sh ;
Awad, Enas M. .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (02) :892-912