Type 2 diabetes mellitus is associated with increased left ventricular mass independent of coronary artery volume

AIM: To determine the relationship of left ventricular mass (LVM) and coronary artery volume in diabetic patients and the controls. MATERIALS AND METHODS: This work included 448 consecutive patients (206 patients with diabetes and 242 non-diabetic participants) who underwent coronary computed tomography angiography (CTA) for evaluation of coronary artery disease (CAD). The whole coronary artery tree and the LVM were analysed using a cardiac imaging workstation. Multivariable logistic regression analysis was used to determine the independent association with coronary artery lumen volume to LVM ratio (V/M). RESULTS: The total coronary artery cumulative volume and the coronary cumulative length showed no differences between groups (p>0.05); however, the LVM in patients with diabetes was significantly greater than that in controls (132.46 +/- 45.04 versus 115.82 +/- 29.13, p=0.006), and the total epicardial coronary arterial lumen volume to LVM ratio (V/M) was significantly lower in the diabetic group than in the non-diabetic group (2.02 cm(3)/100+0.73 g versus 2.31 cm(3)/100 +/- 0.82 g, p=0.024). In multivariate logistic regression analysis, diabetes was associated with V/M (odds ratio [OR] 2.027, 95% confidence interval [CI]: 1.462-2.728, p=0.001), and hypertension was not associated with V/M (OR 1.191, 95% CI: 0.978-1.451, p=0.081). CONCLUSION: Patients with diabetes demonstrated a significantly lower coronary CTA-derived coronary V/M than controls. V/M may have an important role as a global measure of coronary vasculature in diabetic patients. (C) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.