A cyclooxygenase (COX) inhibitory biflavonoid from the seeds of Semecarpus anacardium

被引：65

作者：

Selvam, C ^{[1
]}

Jachak, SA ^{[1
]}

机构：

[1] NIPER, Dept Nat Prod, SAS Nagar 160062, Punjab, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 95卷 / 2-3期

关键词：

tetrahydroamentoflavone; semecarpus anacardium; anti-inflammatory activity; cyclooxygenase-1 (COX-1); cyclooxygenase-2 (COX-2);

D O I：

10.1016/j.jep.2004.07.026

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Semecarpus anacardium Linn., Anacardiaceae, is being most commonly used in India for the treatment of rheumatoid arthritis and other inflammatory disorders. Bioactivity guided fractionation of ethyl acetate extract led to the isolation of major active principle, tetrahydroamentoflavone (THA), a biflavonoid. The in vitro cyclooxygenase (COX-1) catalyzed prostaglandin biosynthesis assay of THA gave an IC50 value of 29.5 muM (COX-1) and 40.5% inhibition at 100 mug/mL (COX-2). The in vivo carrageenan induced paw edema assay resulted in dose dependent anti-inflammatory effect of THA and the activity was comparable to that of ibuprofen, one of the well known NSAIDs. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：209 / 212

页数：4

共 14 条

[1] Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2 catalysed prostaglandin biosynthesis [J].