Mechanism of action of nucleoside antibacterial natural product antibiotics

被引：26
|
作者：
Bugg, Timothy D. H. [1 ]
Kerr, Rachel, V [1 ]
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
来源：
JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 12期
基金：
英国工程与自然科学研究理事会;
关键词：
ACETYLMURAMYL-PENTAPEPTIDE-TRANSLOCASE; PSEUDOMONAS-AERUGINOSA ACTIVITY; SPHEROPLAST FORMING ACTIVITY; MUREIDOMYCINS-A-D; GENE-CLUSTER; PACIDAMYCIN GROUP; ESCHERICHIA-COLI; PEPTIDYLNUCLEOSIDE ANTIBIOTICS; ANTIMYCOBACTERIAL ACTIVITY; HETEROLOGOUS EXPRESSION;
D O I：
10.1038/s41429-019-0227-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This article reviews the structures and biological activities of several classes of uridine-containing nucleoside antibiotics (tunicamycins, mureidomycins/pacidamycins/sansanmycins, liposidomycins/caprazamycins, muraymycins, capuramycins) that target translocase MraY on the peptidoglycan biosynthetic pathway. In particular, recent advances in structure-function studies, and recent X-ray crystal structures of translocase MraY complexed with muraymycin D2 and tunicamycin are described. The inhibition of other phospho-nucleotide transferase enzymes related to MraY by nucleoside antibiotics and analogues is also reviewed.
引用
收藏
页码：865 / 876
页数：12
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