Profiles of Volatile Biomarkers Detect Tuberculosis from Skin

被引：45

作者：

Vishinkin, Rotem ^{[1
,2
]}

Busool, Rami ^{[1
,2
]}

Mansour, Elias ^{[1
,2
]}

Fish, Falk ^{[1
,2
]}

Esmail, Ali ^{[3
,4
,5
]}

Kumar, Parveen ^{[6
]}

Gharaa, Alaa ^{[1
,2
]}

Cancilla, John C. ^{[7
]}

Torrecilla, Jose S. ^{[8
]}

Skenders, Girts ^{[9
,10
]}

Leja, Marcis ^{[9
,10
]}

Dheda, Keertan ^{[3
,4
,5
,11
]}

Singh, Sarman ^{[6
]}

Haick, Hossam ^{[1
,2
]}

机构：

[1] Technion Israel Inst Technol, Dept Chem Engn, IL-3200003 Haifa, Israel

[2] Technion Israel Inst Technol, Russell Berrie Nanotechnol Inst, IL-3200003 Haifa, Israel

[3] Univ Cape Town, Ctr Lung Infect & Immun, Dept Med, Div Pulmonol, ZA-7925 Cape Town, South Africa

[4] Univ Cape Town, UCT Lung Inst, ZA-7925 Cape Town, South Africa

[5] Univ Cape Town, South African MRC UCT Ctr Study Antimicrobial Res, ZA-7925 Cape Town, South Africa

[6] All India Inst Med Sci, New Delhi 110029, India

[7] Scintillon Inst, San Diego, CA 92121 USA

[8] Univ Complutense Madrid, Dept Chem & Mat Engn, Madrid 28040, Spain

[9] Univ Latvia, Inst Clin & Prevent Med, LV-1079 Riga, Latvia

[10] Riga East Univ Hosp, LV-1079 Riga, Latvia

[11] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect Biol, London WC1E 7HT, England

来源：

ADVANCED SCIENCE | 2021年 / 8卷 / 15期

基金：

欧盟地平线“2020”;

关键词：

diagnosis; noninvasive approach; point-of-care test; sensor; skin; tuberculosis; wearable device; ORGANIC-COMPOUNDS; MYCOBACTERIUM-TUBERCULOSIS; LUNG-CANCER; THERMAL-DESORPTION; BREATH TEST; TENAX-TA; DEGRADATION; DISEASE; NANOPARTICLES; DIAGNOSIS;

D O I：

10.1002/advs.202100235

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource-limited settings. According to the World Health Organization (WHO), a rapid, sputum-free, and cost-effective triage test for real-time detection of TB is urgently needed. This article reports on a new diagnostic pathway enabling a noninvasive, fast, and highly accurate way of detecting TB. The approach relies on TB-specific volatile organic compounds (VOCs) that are detected and quantified from the skin headspace. A specifically designed nanomaterial-based sensors array translates these findings into a point-of-care diagnosis by discriminating between active pulmonary TB patients and controls with sensitivity above 90%. This fulfills the WHO's triage test requirements and poses the potential to become a TB triage test.

引用

页数：13

共 88 条

[1] Differential Volatile Signatures from Skin, Naevi and Melanoma: A Novel Approach to Detect a Pathological Process [J].