Microwave-assisted syntheses of nucleosides and their precursors

被引：7

作者：

Roy, Vincent ^{[1
]}

Pradere, Ugo ^{[1
]}

Agrofoglio, Luigi A. ^{[1
]}

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, CNRS, UMR 6005, F-45067 Orleans, France

来源：

FUTURE MEDICINAL CHEMISTRY | 2010年 / 2卷 / 02期

关键词：

SUBSTITUTED PYRIMIDINE NUCLEOSIDES; SOLVENT-FREE; EFFICIENT SYNTHESIS; ANTIVIRAL EVALUATION; SELECTIVE ACYLATION; ORGANIC-SYNTHESIS; SPACER ARM; ANALOGS; CHEMISTRY; DRUGS;

D O I：

10.4155/FMC.09.156

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In recent decades, nucleosides analogs have been the cornerstone in the treatment of various diseases, such as AIDS, herpes and hepatitis. More than 40 modified nucleosides are officially approved by the US FDA and represent the major compound class for inhibition of viral replication. By comparison with traditional conditions, microwave irradiation offers a powerful tool that can increase yields and decrease reaction time, with simple manipulation and an environmentally friendly way. Here, we report the latest progress in nucleoside synthesis using microwave irradiation.

引用

页码：177 / 192

页数：16

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